PDCD4

PDCD4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases PDCD4, H731, programmed cell death 4 (neoplastic transformation inhibitor)
External IDs MGI: 107490 HomoloGene: 7879 GeneCards: PDCD4
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

27250

18569

Ensembl

ENSG00000150593

ENSMUSG00000024975

UniProt

Q53EL6
Q5VZS7

Q61823

RefSeq (mRNA)

NM_145341
NM_001199492
NM_014456

NM_001168491
NM_001168492
NM_011050

RefSeq (protein)

NP_055271.2
NP_663314.1

NP_001161963.1
NP_001161964.1
NP_035180.2

Location (UCSC) Chr 10: 110.87 – 110.9 Mb Chr 19: 53.89 – 53.93 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Programmed cell death protein 4 is a protein that in humans is encoded by the PDCD4 gene.[3][4] It is one of the targets of an oncomiR, MIRN21.[5]

Function

This gene encodes a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.[4]

Interactions

PDCD4 has been shown to interact with RPS13[6] and Ribosomal protein L5.[6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Azzoni L, Zatsepina O, Abebe B, Bennett IM, Kanakaraj P, Perussia B (1998). "Differential transcriptional regulation of CD161 and a novel gene, 197/15a, by IL-2, IL-15, and IL-12 in NK and T cells". Journal of immunology. 161 (7): 3493–500. PMID 9759869.
  4. 1 2 EntrezGene 27250
  5. Frankel LB, Christoffersen NR, Jacobsen A, Lindow M, Krogh A, Lund AH (2008). "Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells". The Journal of Biological Chemistry. 283 (2): 1026–33. doi:10.1074/jbc.M707224200. PMID 17991735.
  6. 1 2 Kang MJ, Ahn HS, Lee JY, Matsuhashi S, Park WY (2002). "Up-regulation of PDCD4 in senescent human diploid fibroblasts". Biochemical and Biophysical Research Communications. 293 (1): 617–21. doi:10.1016/S0006-291X(02)00264-4. PMID 12054647.

Further reading


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