PDE2A

PDE2A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1Z1L, 3IBJ, 3ITM, 3ITU, 4C1I, 4D08, 4D09, 4HTX, 4HTZ, 4JIB
Identifiers
Aliases	PDE2A, CGS-PDE, PDE2A1, PED2A4, cGSPDE, phosphodiesterase 2A
External IDs	MGI: 2446107 HomoloGene: 1952 GeneCards: PDE2A
Targeted by Drug
guanosine cyclic 3',5'-phosphate, bay-60-7550, milrinone[1]
Gene ontology Molecular function • nucleotide binding • 3',5'-cyclic-nucleotide phosphodiesterase activity • calcium channel activity • cGMP binding • metal ion binding • cyclic-nucleotide phosphodiesterase activity • protein binding • drug binding • phosphoric diester hydrolase activity • TPR domain binding • hydrolase activity • cGMP-stimulated cyclic-nucleotide phosphodiesterase activity • cAMP binding • protein homodimerization activity • 3',5'-cyclic-AMP phosphodiesterase activity • 3',5'-cyclic-GMP phosphodiesterase activity Cellular component • cytoplasm • cytosol • Golgi apparatus • membrane • plasma membrane • mitochondrial matrix • endoplasmic reticulum • mitochondrion • perinuclear region of cytoplasm • presynaptic membrane • nucleus Biological process • establishment of endothelial barrier • cellular response to transforming growth factor beta stimulus • positive regulation of inflammatory response • cellular response to cGMP • protein targeting to mitochondrion • negative regulation of transcription from RNA polymerase II promoter • monocyte differentiation • cGMP-mediated signaling • cellular response to macrophage colony-stimulating factor stimulus • cellular response to mechanical stimulus • cellular response to drug • positive regulation of vascular permeability • cellular response to granulocyte macrophage colony-stimulating factor stimulus • negative regulation of cAMP biosynthetic process • metabolic process • cAMP-mediated signaling • negative regulation of protein import into nucleus, translocation • signal transduction • negative regulation of vascular permeability • cGMP catabolic process • cAMP catabolic process • calcium ion transmembrane transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5138	207728
Ensembl	ENSG00000186642	ENSMUSG00000030653
UniProt	O00408	Q922S4
RefSeq (mRNA)	NM_001143839 NM_001146209 NM_001243784 NM_002599	NM_001008548 NM_001143848 NM_001143849 NM_001243757 NM_001243758
RefSeq (protein)	NP_001137311.1 NP_001139681.1 NP_001230713.1 NP_002590.1	n/a
Location (UCSC)	Chr 11: 72.58 – 72.67 Mb	Chr 7: 101.42 – 101.51 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

cGMP-dependent 3',5'-cyclic phosphodiesterase is an enzyme that in humans is encoded by the PDE2A gene.^[4][5]

References

1. "Drugs that physically interact with cGMP-dependent 3',5'-cyclic phosphodiesterase view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Rosman GJ, Martins TJ, Sonnenburg WK, Beavo JA, Ferguson K, Loughney K (Aug 1997). "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase". Gene. 191 (1): 89–95. doi:10.1016/S0378-1119(97)00046-2. PMID 9210593.
5. "Entrez Gene: PDE2A phosphodiesterase 2A, cGMP-stimulated".

Further reading

• Witzenrath M, Gutbier B, Schmeck B, et al. (2005). "Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia". Critical Care Medicine. 105 (9): 584–590. doi:10.1097/CCM.0b013e3181959814. PMID 19114892.
• Seybold J, Thomas D, Witzenrath M, et al. (2009). "Tumor necrosis factor-alpha-dependent expression of phosphodiesterase 2: role in endothelial hyperpermeability". Blood. 105 (9): 3569–3576. doi:10.1182/blood-2004-07-2729. PMID 15650061.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Martinez SE, Wu AY, Glavas NA, et al. (2002). "The two GAF domains in phosphodiesterase 2A have distinct roles in dimerization and in cGMP binding". Proc. Natl. Acad. Sci. U.S.A. 99 (20): 13260–13265. doi:10.1073/pnas.192374899. PMC 130621. PMID 12271124.
• Manns JM, Brenna KJ, Colman RW, Sheth SB (2002). "Differential regulation of human platelet responses by cGMP inhibited and stimulated cAMP phosphodiesterases". Thromb. Haemost. 87 (5): 873–9. PMID 12038792.
• Zauli G, Milani D, Mirandola P, et al. (2001). "HIV-1 Tat protein down-regulates CREB transcription factor expression in PC12 neuronal cells through a phosphatidylinositol 3-kinase/AKT/cyclic nucleoside phosphodiesterase pathway". FASEB J. 15 (2): 483–491. doi:10.1096/fj.00-0354com. PMID 11156964.
• Sadhu K, Hensley K, Florio VA, Wolda SL (1999). "Differential expression of the cyclic GMP-stimulated phosphodiesterase PDE2A in human venous and capillary endothelial cells". J. Histochem. Cytochem. 47 (7): 895–906. doi:10.1177/002215549904700707. PMID 10375378.