PEG-PVA

Polyethylene glycol–polyvinyl alcohol (PEG-PVA) brand name Kollicoat IR (BASF) is a novel multifunctional excipient[1] used as a pill binder as well as a wet binder. The formulation is composed of 25% PEG and 75% PVA; where the vinyl alcohol moieties are grafted on a polyethylene glycol backbone.[2]

Physico-chemical properties of PEG-PVA
2D structure Statistic Results for PEG-PVA
Molecular weight 45,000 Dalton
pH 5—8
k-value (1% water) 31—34
Solubility
Water
0.07 N HCl (pH 1.2)
Phosphate buffer, pH 6.8
Water/ethanol (1:1)
Organic solvents

>30%
>30%
>30%
20%
Insoluble
Viscosity at 20wt% (water) 115 mPas
Oxygen permeability 104 cm3/100μm/m2.d
Water vapor permeability 510 cm3/100μm/m2.d
Elongation at break
(film thickness 100 μm)
105% @ 54% RH
Disintegration time
(film thickness 100 μm)
0:44 sec. @ pH 1.2, pH 6.8
Dissolution time
(film thickness 100 μm)
1:30 min. @ pH 1.2, pH 6.8
Surface tension, 23 °C 10wt% solution: 44 mN/m2
20wt% solution: 41 mN/m2
PEG (free) None

See also

References

  1. Multifunctional Excipients: The Smart Excipients. Department of pharmaceutics, MVP Samaj’s College of Pharmacy, Nasik 02
  2. American Pharmaceutical Review (Periodical) Vol. 18 Iss. 7 Nov./Dec. 2015


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