PEG 400

Polyethylene glycol

Names
IUPAC name Polyethylene glycol
Identifiers
CAS Number	25322-68-3
Properties
Chemical formula	C2nH4n+2On+1, n = 8.2 to 9.1
Molar mass	380-420 g/mol
Density	1.128 g/cm^3
Melting point	4 to 8 °C (39 to 46 °F; 277 to 281 K)
Viscosity	90.0 cSt at 25 °C, 7.3 cSt at 99 °C
Hazards
Flash point	238 °C (460 °F; 511 K)
Lethal dose or concentration (LD, LC):
LD50 (median dose)	30 mL/kg, orally in rats
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.

Chemical properties

PEG 400 is strongly hydrophilic. The partition coefficient of PEG 400 between hexane and water is 0.000015 (log${\displaystyle P=-4.8}$), indicating that when PEG 400 is mixed with water and hexane, there are only 15 parts of PEG 400 in the hexane layer per 1 million parts of PEG 400 in the water layer.^[1]

PEG 400 is soluble in water, acetone, alcohols, benzene, glycerin, glycols, and aromatic hydrocarbons, and is slightly soluble in aliphatic hydrocarbons.

References

1. T. Y. Ma; D. Hollander; P. Krugliak; K. Katz (1990). "PEG 400, a hydrophilic molecular probe for measuring intestinal permeability". Gastroenterology. 98 (1): 39–46. PMID 2293598.

• The Merck Index, 11th Edition
• Handbook of Pharmaceutical Excipients