PHLDB2

PHLDB2
Identifiers
Aliases	PHLDB2, LL5b, LL5beta, pleckstrin homology like domain family B member 2
External IDs	MGI: 2444981 HomoloGene: 17100 GeneCards: PHLDB2
Gene ontology Molecular function • protein binding • cadherin binding involved in cell-cell adhesion Cellular component • plasma membrane • intermediate filament cytoskeleton • basal cortex • cell leading edge • membrane • focal adhesion • cytoplasm • cell-cell adherens junction Biological process • negative regulation of wound healing, spreading of epidermal cells • regulation of epithelial to mesenchymal transition • regulation of microtubule cytoskeleton organization • positive regulation of basement membrane assembly involved in embryonic body morphogenesis • negative regulation of stress fiber assembly • regulation of gastrulation • microtubule cytoskeleton organization • negative regulation of focal adhesion assembly • establishment of protein localization • cell-cell adhesion Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	90102	208177
Ensembl	ENSG00000144824	ENSMUSG00000033149
UniProt	Q86SQ0	Q8K1N2
RefSeq (mRNA)	NM_145753 NM_001134437 NM_001134438 NM_001134439	NM_001252442 NM_153412
RefSeq (protein)	NP_001127909.1 NP_001127910.1 NP_001127911.1 NP_665696.1	NP_001239371.1 NP_700461.2
Location (UCSC)	Chr 3: 111.73 – 111.98 Mb	Chr 16: 45.75 – 45.95 Mb
PubMed search	[1]	[2]
Wikidata

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Pleckstrin homology-like domain family B member 2 is a protein that in humans is encoded by the PHLDB2 gene.^[3][4]

Interactions

PHLDB2 has been shown to interact with FLNC.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Paranavitane V, Coadwell WJ, Eguinoa A, Hawkins PT, Stephens L (Jan 2003). "LL5beta is a phosphatidylinositol (3,4,5)-trisphosphate sensor that can bind the cytoskeletal adaptor, gamma-filamin". J Biol Chem. 278 (2): 1328–35. doi:10.1074/jbc.M208352200. PMID 12376540.
4. "Entrez Gene: PHLDB2 pleckstrin homology-like domain, family B, member 2".

Further reading

• Dowler S, Currie RA, Campbell DG, Deak M, Kular G, Downes CP, Alessi DR (October 2000). "Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities". Biochem. J. 351 (Pt 1): 19–31. doi:10.1042/0264-6021:3510019. PMC 1221362. PMID 11001876.
• Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, Ohtsuka T, Higa S, Kitajima I, Demmers J, Galjart N, Houtsmuller AB, Grosveld F, Akhmanova A (July 2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Dev. Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950.
• Hotta A, Kawakatsu T, Nakatani T, Sato T, Matsui C, Sukezane T, Akagi T, Hamaji T, Grigoriev I, Akhmanova A, Takai Y, Mimori-Kiyosue Y (May 2010). "Laminin-based cell adhesion anchors microtubule plus ends to the epithelial cell basal cortex through LL5alpha/beta". J. Cell Biol. 189 (5): 901–17. doi:10.1083/jcb.200910095. PMC 2878951. PMID 20513769.