PLD3
PLD3 | |||||||||||||||||
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Identifiers | |||||||||||||||||
Aliases | PLD3, AD19, HU-K4, HUK4, phospholipase D family member 3 | ||||||||||||||||
External IDs | MGI: 1333782 HomoloGene: 7893 GeneCards: PLD3 | ||||||||||||||||
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Orthologs | |||||||||||||||||
Species | Human | Mouse | |||||||||||||||
Entrez | |||||||||||||||||
Ensembl | |||||||||||||||||
UniProt | |||||||||||||||||
RefSeq (mRNA) | |||||||||||||||||
RefSeq (protein) | |||||||||||||||||
Location (UCSC) | Chr 19: 40.35 – 40.38 Mb | Chr 7: 27.53 – 27.55 Mb | |||||||||||||||
PubMed search | [1] | [2] | |||||||||||||||
Wikidata |
View/Edit Human | View/Edit Mouse |
Phospholipase D family, member 3 is a protein that in humans is encoded by the PLD3 gene.[3]
Function
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk.[3]
References
Further reading
- Munck A, Böhm C, Seibel NM, Hashemol Hosseini Z, Hampe W (Apr 2005). "Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum". The FEBS Journal. 272 (7): 1718–26. doi:10.1111/j.1742-4658.2005.04601.x. PMID 15794758.
- Idkowiak-Baldys J, Baldys A, Raymond JR, Hannun YA (Aug 2009). "Sustained receptor stimulation leads to sequestration of recycling endosomes in a classical protein kinase C- and phospholipase D-dependent manner". The Journal of Biological Chemistry. 284 (33): 22322–31. doi:10.1074/jbc.M109.026765. PMID 19525236.
- Miyamoto-Sato E, Fujimori S, Ishizaka M, Hirai N, Masuoka K, Saito R, Ozawa Y, Hino K, Washio T, Tomita M, Yamashita T, Oshikubo T, Akasaka H, Sugiyama J, Matsumoto Y, Yanagawa H (2010). "A comprehensive resource of interacting protein regions for refining human transcription factor networks". PLOS ONE. 5 (2): e9289. doi:10.1371/journal.pone.0009289. PMC 2827538. PMID 20195357.
- Walker LC, Waddell N, Ten Haaf A, Grimmond S, Spurdle AB (Nov 2008). "Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers". Breast Cancer Research and Treatment. 112 (2): 229–36. doi:10.1007/s10549-007-9848-5. PMID 18095154.
- Pridgeon JW, Webber EA, Sha D, Li L, Chin LS (Jan 2009). "Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes". The FEBS Journal. 276 (1): 118–31. doi:10.1111/j.1742-4658.2008.06760.x. PMC 2647816. PMID 19019082.
- Zhang J, Chen S, Zhang S, Lu Z, Yang H, Wang H (Oct 2009). "[Over-expression of phospholipase D3 inhibits Akt phosphorylation in C2C12 myoblasts]". Sheng Wu Gong Cheng Xue Bao = Chinese Journal of Biotechnology. 25 (10): 1524–31. PMID 20112697.
- Russo P, Venezia A, Lauria F, Strazzullo P, Cappuccio FP, Iacoviello L, Barba G, Siani A (Apr 2006). "HindIII(+/-) polymorphism of the Y chromosome, blood pressure, and serum lipids: no evidence of association in three white populations". American Journal of Hypertension. 19 (4): 331–8. doi:10.1016/j.amjhyper.2005.10.003. PMID 16580565.
- Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, Long J, Stern D, Tammana H, Helt G, Sementchenko V, Piccolboni A, Bekiranov S, Bailey DK, Ganesh M, Ghosh S, Bell I, Gerhard DS, Gingeras TR (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
- Pedersen KM, Finsen B, Celis JE, Jensen NA (Nov 1998). "Expression of a novel murine phospholipase D homolog coincides with late neuronal development in the forebrain". The Journal of Biological Chemistry. 273 (47): 31494–504. doi:10.1074/jbc.273.47.31494. PMID 9813063.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.