PLD3

PLD3
Identifiers
Aliases PLD3, AD19, HU-K4, HUK4, phospholipase D family member 3
External IDs MGI: 1333782 HomoloGene: 7893 GeneCards: PLD3
Orthologs
Species Human Mouse
Entrez

23646

18807

Ensembl

ENSG00000105223

ENSMUSG00000003363

UniProt

Q8IV08

O35405

RefSeq (mRNA)

NM_001031696
NM_001291311
NM_012268

NM_011116
NM_001317355

RefSeq (protein)

NP_001026866.1
NP_001278240.1
NP_036400.2

NP_035246.1
NP_001304284.1

Location (UCSC) Chr 19: 40.35 – 40.38 Mb Chr 7: 27.53 – 27.55 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Phospholipase D family, member 3 is a protein that in humans is encoded by the PLD3 gene.[3]

Function

This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk.[3]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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