PPIL2

PPIL2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZKC
Identifiers
Aliases	PPIL2, CYC4, CYP60, Cyp-60, UBOX7, hCyP-60, peptidylprolyl isomerase like 2
External IDs	MGI: 2447857 HomoloGene: 8643 GeneCards: PPIL2
Gene ontology Molecular function • ubiquitin-ubiquitin ligase activity • ligase activity • protein binding • isomerase activity • peptidyl-prolyl cis-trans isomerase activity • ubiquitin protein ligase activity • ubiquitin-protein transferase activity Cellular component • cytoplasm • Golgi lumen • plasma membrane • nucleus • nucleoplasm Biological process • protein polyubiquitination • protein localization to plasma membrane • protein folding • protein ubiquitination • leukocyte migration • protein peptidyl-prolyl isomerization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23759	66053
Ensembl	ENSG00000100023	ENSMUSG00000022771
UniProt	Q13356	Q9D787
RefSeq (mRNA)	NM_014337 NM_148175 NM_148176 NM_001317996	NM_001252444 NM_001252445 NM_144954
RefSeq (protein)	NP_055152.1 NP_680480.1 NP_680481.1 NP_001304925.1	NP_001239373.1 NP_001239374.1 NP_659203.1
Location (UCSC)	Chr 22: 21.65 – 21.7 Mb	Chr 16: 17.09 – 17.11 Mb
PubMed search	[1]	[2]
Wikidata

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Peptidyl-prolyl cis-trans isomerase-like 2 is an enzyme that in humans is encoded by the PPIL2 gene.^[3][4]

This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. This protein interacts with the proteinase inhibitor eglin c and is localized in the nucleus. Multiple transcript variants encoding different isoforms have been found for this gene.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP, et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
4. "Entrez Gene: PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2".

Further reading

• Wang BB, Hayenga KJ, Payan DG, Fisher JM (1996). "Identification of a nuclear-specific cyclophilin which interacts with the proteinase inhibitor eglin c". Biochem. J. 314 (1): 313–9. PMC 1217042. PMID 8660300.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Pushkarsky T, Yurchenko V, Vanpouille C, et al. (2005). "Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60". J. Biol. Chem. 280 (30): 27866–71. doi:10.1074/jbc.M503770200. PMID 15946952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Davis TL, Walker JR, Campagna-Slater V, et al. (2010). "Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases". PLoS Biol. 8 (7): e1000439. doi:10.1371/journal.pbio.1000439. PMC 2911226. PMID 20676357.