Protein phosphatase methylesterase-1
Protein phosphatase methylesterase-1 | |||||||||
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Identifiers | |||||||||
EC number | 3.1.1.89 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Protein phosphatase methylesterase-1 (EC 3.1.1.89, PME-1, PPME1) is an enzyme with systematic name (phosphatase 2A protein)-leucine ester acylhydrolase.[1][2] This enzyme catalyses the following chemical reaction
- [phosphatase 2A protein]-leucine methyl ester + H2O [phosphatase 2A protein]-leucine + methanol
A key regulator of protein phosphatase 2A.
References
- ↑ Ogris, E.; Du, X.; Nelson, K.C.; Mak, E.K.; Yu, X.X.; Lane, W.S.; Pallas, D.C. (1999). "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A". J. Biol. Chem. 274 (20): 14382–14391. doi:10.1074/jbc.274.20.14382. PMC 3503312. PMID 10318862.
- ↑ Xing, Y.; Li, Z.; Chen, Y.; Stock, J.B.; Jeffrey, P.D.; Shi, Y. (2008). "Structural mechanism of demethylation and inactivation of protein phosphatase 2A". Cell. 133 (1): 154–163. doi:10.1016/j.cell.2008.02.041. PMID 18394995.
External links
- Protein phosphatase methylesterase-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
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