PPP6C

PPP6C
Identifiers
Aliases	PPP6C, PP6, PP6C, protein phosphatase 6 catalytic subunit
External IDs	MGI: 1915107 HomoloGene: 68273 GeneCards: PPP6C
Gene ontology Molecular function • protein serine/threonine phosphatase activity • protein binding • phosphoprotein phosphatase activity • hydrolase activity • metal ion binding Cellular component • cytoplasm • cytosol • Golgi membrane Biological process • G1/S transition of mitotic cell cycle • cell cycle • protein dephosphorylation • COPII vesicle coating Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5537	67857
Ensembl	ENSG00000119414	ENSMUSG00000026753
UniProt	O00743	Q9CQR6
RefSeq (mRNA)	NM_001123355 NM_001123369 NM_002721	NM_024209
RefSeq (protein)	NP_001116827.1 NP_001116841.1 NP_002712.1	NP_077171.1
Location (UCSC)	Chr 9: 125.15 – 125.19 Mb	Chr 2: 39.19 – 39.23 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein phosphatase 6 catalytic subunit is an enzyme that in humans is encoded by the PPP6C gene.^[3][4]

Interactions

PPP6C has been shown to interact with IGBP1.^[5][6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Bastians H, Krebber H, Vetrie D, Hoheisel J, Lichter P, Ponstingl H, Joos S (Jul 1997). "Localization of the novel serine/threonine protein phosphatase 6 gene (PPP6C) to human chromosome Xq22.3". Genomics. 41 (2): 296–7. doi:10.1006/geno.1997.4640. PMID 9143513.
4. "Entrez Gene: PPP6C protein phosphatase 6, catalytic subunit".
5. Gingras, Anne-Claude; Caballero Michael; Zarske Marcel; Sanchez Amy; Hazbun Tony R; Fields Stanley; Sonenberg Nahum; Hafen Ernst; Raught Brian; Aebersold Ruedi (Nov 2005). "A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity". Mol. Cell Proteomics. United States. 4 (11): 1725–40. doi:10.1074/mcp.M500231-MCP200. ISSN 1535-9476. PMID 16085932.
6. Chen, J; Peterson R T; Schreiber S L (Jun 1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6". Biochem. Biophys. Res. Commun. UNITED STATES. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. ISSN 0006-291X. PMID 9647778.

Further reading

• Bastians H, Ponstingl H (1997). "The novel human protein serine/threonine phosphatase 6 is a functional homologue of budding yeast Sit4p and fission yeast ppe1, which are involved in cell cycle regulation.". J. Cell. Sci. 109 (Pt 12): 2865–74. PMID 9013334.
• Chen J, Peterson RT, Schreiber SL (1998). "Alpha 4 associates with protein phosphatases 2A, 4, and 6.". Biochem. Biophys. Res. Commun. 247 (3): 827–32. doi:10.1006/bbrc.1998.8792. PMID 9647778.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science. 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
• Nasu-Nishimura Y, Hayashi T, Ohishi T, et al. (2006). "Role of the Rho GTPase-activating protein RICS in neurite outgrowth.". Genes Cells. 11 (6): 607–14. doi:10.1111/j.1365-2443.2006.00966.x. PMID 16716191.
• Stefansson B, Brautigan DL (2006). "Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon.". J. Biol. Chem. 281 (32): 22624–34. doi:10.1074/jbc.M601772200. PMID 16769727.
• Stefansson B, Brautigan DL (2007). "Protein phosphatase PP6 N terminal domain restricts G1 to S phase progression in human cancer cells.". Cell Cycle. 6 (11): 1386–92. doi:10.4161/cc.6.11.4276. PMID 17568194.