PRSS3

PRSS3
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1H4W, 2R9P, 3L33, 3L3T, 3P92, 3P95, 4DG4, 4U30, 4U32, 5C67
Identifiers
Aliases	PRSS3, MTG, PRSS4, T9, TRY3, TRY4, protease, serine 3
External IDs	MGI: 102757 HomoloGene: 106639 GeneCards: PRSS3
Gene ontology Molecular function • calcium ion binding • peptidase activity • serine-type endopeptidase activity • protein binding • hydrolase activity • metal ion binding • serine-type peptidase activity Cellular component • extracellular fluid • extracellular region • extracellular exosome Biological process • digestion • cobalamin metabolic process • zymogen activation • endothelial cell migration • proteolysis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	5646	22074
Ensembl	ENSG00000010438	ENSMUSG00000054106
UniProt	P35030	n/a
RefSeq (mRNA)	NM_001197097 NM_001197098 NM_002771 NM_007343	NM_011646
RefSeq (protein)	NP_001184026.2 NP_001184027.1 NP_002762.2 NP_031369.2	n/a
Location (UCSC)	Chr 9: 33.75 – 33.8 Mb	Chr 6: 41.3 – 41.31 Mb
PubMed search	[1]	[2]
Wikidata

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Protease, serine, 3 is a protein that in humans is encoded by the PRSS3 gene. ^[3]

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Protease, serine, 3". Retrieved 2013-08-20.

Further reading

• Koistinen, H.; Koistinen, R.; Zhang, W. -M.; Valmu, L.; Stenman, U. -H. (2009). "Nexin-1 inhibits the activity of human brain trypsin". Neuroscience. 160 (1): 97–102. doi:10.1016/j.neuroscience.2009.02.042. PMID 19249338.
• Tani, T.; Kawashima, I.; Mita, K.; Takiguchi, Y. (1990). "Nucleotide sequence of the human pancreatic trypsinogen III cDNA". Nucleic Acids Research. 18 (6): 1631. doi:10.1093/nar/18.6.1631. PMC 330537. PMID 2326201.
• Hayashi, H.; Kohno, T.; Yasui, K.; Murota, H.; Kimura, T.; Duncan, G. S.; Nakashima, T.; Yamamoto, K.; Katayama, I.; Ma, Y.; Chua, K. J.; Suematsu, T.; Shimokawa, I.; Akira, S.; Kubo, Y.; Mak, T. W.; Matsuyama, T. (2011). "Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription". Proceedings of the National Academy of Sciences. 108 (46): 18766–18771. doi:10.1073/pnas.1116273108. PMC 3219097. PMID 22042864.
• Salameh, M. A.; Robinson, J. L.; Navaneetham, D.; Sinha, D.; Madden, B. J.; Walsh, P. N.; Radisky, E. S. (2009). "The Amyloid Precursor Protein/Protease Nexin 2 Kunitz Inhibitor Domain is a Highly Specific Substrate of Mesotrypsin". Journal of Biological Chemistry. 285 (3): 1939–1949. doi:10.1074/jbc.M109.057216. PMC 2804352. PMID 19920152.
• Masson, E.; Le Maréchal, C. D.; Chen, J. M.; Férec, C. (2008). "Absence of Mesotrypsinogen Gene (PRSS3) Copy Number Variations in Patients with Chronic Pancreatitis". Pancreas. 37 (2): 227–228. doi:10.1097/MPA.0b013e3181654b6a. PMID 18665091.
• Nyaruhucha, C. N.; Kito, M.; Fukuoka, S. I. (1997). "Identification and expression of the cDNA-encoding human mesotrypsin(ogen), an isoform of trypsin with inhibitor resistance". The Journal of Biological Chemistry. 272 (16): 10573–10578. doi:10.1074/jbc.272.16.10573. PMID 9099703.
• Knecht, W.; Cottrell, G. S.; Amadesi, S.; Mohlin, J.; Skåregärde, A.; Gedda, K.; Peterson, A.; Chapman, K.; Hollenberg, M. D.; Vergnolle, N.; Bunnett, N. W. (2007). "Trypsin IV or Mesotrypsin and p23 Cleave Protease-activated Receptors 1 and 2 to Induce Inflammation and Hyperalgesia". Journal of Biological Chemistry. 282 (36): 26089–26100. doi:10.1074/jbc.M703840200. PMID 17623652.
• Ferreira, M. A. R.; O'Donovan, M. C.; Meng, Y. A.; Jones, I. R.; Ruderfer, D. M.; Jones, L.; Fan, J.; Kirov, G.; Perlis, R. H.; Green, E. K.; Smoller, J. W.; Grozeva, D.; Stone, J.; Nikolov, I.; Chambert, K.; Hamshere, M. L.; Nimgaonkar, V. L.; Moskvina, V.; Thase, M. E.; Caesar, S.; Sachs, G. S.; Franklin, J.; Gordon-Smith, K.; Ardlie, K. G.; Gabriel, S. B.; Fraser, C.; Blumenstiel, B.; Defelice, M.; Breen, G.; Gill, M. (2008). "Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder". Nature Genetics. 40 (9): 1056–1058. doi:10.1038/ng.209. PMC 2703780. PMID 18711365.
• Huntington, J. A.; Read, R. J.; Carrell, R. W. (2000). "Structure of a serpin-protease complex shows inhibition by deformation". Nature. 407 (6806): 923–926. doi:10.1038/35038119. PMID 11057674.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.