PSCDBP

CYTIP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z17
Identifiers
Aliases	CYTIP, B3-1, CASP, CYBR, CYTHIP, HE, PSCDBP, cytohesin 1 interacting protein
External IDs	MGI: 2183535 HomoloGene: 3167 GeneCards: CYTIP
Gene ontology Molecular function • protein binding Cellular component • cytoplasm • endosome • cell cortex • early endosome • nucleoplasm Biological process • regulation of cell adhesion Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9595	227929
Ensembl	ENSG00000115165	ENSMUSG00000026832
UniProt	O60759	Q91VY6
RefSeq (mRNA)	NM_004288	NM_139200
RefSeq (protein)	NP_004279.3	NP_631939.1
Location (UCSC)	Chr 2: 157.41 – 157.49 Mb	Chr 2: 58.13 – 58.2 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.^[3][4][5][6]

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta. 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278.
4. Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet. 84 (1-2): 95. doi:10.1159/000015226. PMID 10343115.
5. Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA. 99 (5): 2625–9. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758.
6. "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein".

Further reading

• Mansour M, Lee SY, Pohajdak B (2002). "The N-terminal coiled coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with the scaffolding protein CASP.". J. Biol. Chem. 277 (35): 32302–9. doi:10.1074/jbc.M202898200. PMID 12052827.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Boehm T, Hofer S, Winklehner P, et al. (2003). "Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.". EMBO J. 22 (5): 1014–24. doi:10.1093/emboj/cdg101. PMC 150334. PMID 12606567.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Chen Q, Coffey A, Bourgoin SG, Gadina M (2006). "Cytohesin binder and regulator augments T cell receptor-induced nuclear factor of activated T Cells.AP-1 activation through regulation of the JNK pathway.". J. Biol. Chem. 281 (29): 19985–94. doi:10.1074/jbc.M601629200. PMID 16702224.
• MacNeil AJ, Mansour M, Pohajdak B (2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes.". Biochem. Biophys. Res. Commun. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID 17577583.