Pachymic acid

Pachymic acid
Names
IUPAC name
3-Acetoxy-16-hydroxy-24-methylenelanost-8-en-21-oic acid
Systematic IUPAC name
(2R)-2-[(3S,5R,10S,13R,14R,16R,17R)-3-acetyloxy-16-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
Identifiers
29070-92-6 YesY
3D model (Jmol) Interactive image
ChEMBL ChEMBL468034
ChemSpider 280037 YesY
KEGG C17044
PubChem 5484385
Properties
C33H52O5
Molar mass 528.76 g/mol
Density 1.1±0.1 g/cm3
Boiling point 612.2±55.0 °C at 760 mmHg
Hazards
Flash point 184.7±25.0 °C
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Pachymic acid is a natural triterpenoid chemical that can be extracted from the root of various Pinus species, where it is produced by parasitic fungus Wolfiporia extensa (synonym Wolfiporia cocos). The dried sclerotia of the fungus is used as a traditional Chinese medicine, and pachymic acid is one of the major bioactive components of it.[1]

Effects

Pachymic acid is known to inhibit the Epstein-Barr virus and to inhibit the snake venom phospholipase A2.[2] It also has antitumor and anti-inflammatory properties.[1]

References

  1. 1 2 Shu, Shaohua; Chen, Bei; Zhou, Mengchun; Zhao, Xinmei; Xia, Haiyang; Wang, Mo (2013). "De Novo Sequencing and Transcriptome Analysis of Wolfiporia cocos to Reveal Genes Related to Biosynthesis of Triterpenoids". PLOS ONE. 8 (8): e71350. doi:10.1371/journal.pone.0071350. PMC 3743799Freely accessible. PMID 23967197.
  2. "Pachymic acid Biological Test Results". PubChem compound database. 3 March 2016.


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