Patrik Rorsman

Patrik Rorsman

Patrik Rorsman in 2014, portrait via the Royal Society
Born 1958/1959 (age 56–58)[1]
Lund, Sweden[1]
Nationality Swedish[2]
Fields
Institutions
Alma mater Uppsala University (PhD)
Thesis Patch-clamp studies on pancreatic glucagon- and insulin-secreting cells (1986)
Doctoral students
  • Nicola Beer[4]
  • Jonathan Walker[5]
  • Laura McCulloch[6]
Notable awards
Website
www.ocdem.ox.ac.uk/patrik-rorsman

Patrik Rorsman FRS FMedSci is Professor of Diabetic Medicine at the Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), in the Radcliffe Department of Medicine at the University of Oxford[2][8][9] and a fellow of Harris Manchester College, Oxford.[10][11]

Education

Rorsman was educated at Uppsala University in Sweden where he was awarded a PhD in 1986 for patch clamp studies of pancreatic cells and their secretion of glucagon and insulin.[12]

Career

Rorsman was the Canadian Excellence in Research Chair (CERC) in Diabetes[2][13][14] at the University of Alberta in Edmonton, before being appointed a Professor at the University of Oxford in 2011.[2]

Research

Rorsman's research investigates exocytosis, ion channels and diabetes mellitus type 2.[3][15][16][17][18][19][20][21][22][23] His research been funded by the Medical Research Council (MRC),[24] the Royal Society, the Wolfson Foundation, the Knut and Alice Wallenberg Foundation,[1] the Wellcome Trust and the Government of Canada.[11]

Awards and honours

Rorsman was elected a Fellow of the Royal Society (FRS) in 2014. His nomination reads:

“ Patrik Rorsman is an outstanding cell physiologist who has made distinguished contributions to our understanding of how the insulin- and glucagon-producing cells of the pancreatic islets regulate the plasma glucose concentration. His pioneering work is a shining example of post-genomic experimental diabetes research that integrates an unusual breadth of sophisticated methods and has clinical implications. It has led to the identification of key processes that become disrupted in type 2 diabetes, and shed light on the causal relationship between obesity and diabetes. He has also trained a school of excellent young investigators.[7] ”

Rorsman was elected a Fellow of the Academy of Medical Sciences (FMedSci) in 2010. His nomination reads:

“ Patrik Rorsman is Professor of Diabetic Medicine at the University of Oxford. He has been at the forefront of pancreatic islets research for more than 20 years. His work integrates an unusual variety and breadth of sophisticated high-resolution methods including the whole-islet patch-clamp technique which has helped to bridge the gap between patch-clamp measurements on isolated cultured cells and hormone release by whole islets. Patrik’s work also covers human islet cells, which has revealed important differences between ß-cells in man and experimental animals that are likely to be highly relevant to the understanding of the causes and treatment of human diabetes.[25] ”

Rorsman was awarded the Minkowski Prize in 1996, the Göran Gustafsson Prize in 2003 and the Albert Renold Prize in 2013.

References

  1. 1 2 3 Wallenberg researcher aiming to solve the riddle of diabetes, akademimiliv.se
  2. 1 2 3 4 Gewin, V. (2012). "Turning point: Patrik Rorsman". Nature. 492 (7428): 301. doi:10.1038/nj7428-301a.
  3. 1 2 Professor Patrik Rorsman (OXION Member), University of Oxford
  4. ↑ Beer, Nicola (2011). The role of genetic variation in glucokinase and glucokinase regulatory protein in diabetes and related traits (DPhil thesis). University of Oxford.
  5. ↑ Walker, Jonathan Neil (2011). The influence of donor body mass index on human pancreatic islet function, structure and islet transplant outcome (DPhil thesis). University of Oxford.
  6. ↑ McCulloch, Laura Jade (2011). The molecular genetics of insulin secretion and signalling (DPhil thesis). University of Oxford.
  7. 1 2 "Professor Patrik Rorsman FMedSci FRS". London: The Royal Society. Archived from the original on 2014-01-01.
  8. ↑ Patrik Rorsman's publications indexed by the Scopus bibliographic database, a service provided by Elsevier. (subscription required)
  9. ↑ List of publications from Microsoft Academic Search
  10. ↑ Professor Patrik Rorsman, Harris Manchester College, University of Oxford
  11. 1 2 Patrik Rorsman leaves $10M Edmonton research grant behind, returns to England, National Post, 2012-11-14
  12. ↑ Rorsman, Patrik (1986). Patch-clamp studies on pancreatic glucagon- and insulin-secreting cells (PhD thesis). Uppsala University.
  13. ↑ The value of the Canada Excellence Research Chairs (CERC) program, The Lab and Field
  14. ↑ Patrik Rorsman is the new Canada Excellence Research Chair in Diabetes on YouTube, University of Alberta
  15. ↑ Ashcroft, F. M.; Rorsman, P. (1989). "Electrophysiology of the pancreatic β-cell". Progress in Biophysics and Molecular Biology. 54 (2): 87. doi:10.1016/0079-6107(89)90013-8. PMID 2484976.
  16. ↑ Poy, M. N.; Eliasson, L.; Krutzfeldt, J.; Kuwajima, S.; Ma, X.; MacDonald, P. E.; Pfeffer, S. B.; Tuschl, T.; Rajewsky, N.; Rorsman, P.; Stoffel, M. (2004). "A pancreatic islet-specific microRNA regulates insulin secretion". Nature. 432 (7014): 226–30. doi:10.1038/nature03076. PMID 15538371.
  17. ↑ Rorsman, P.; Renstr�m, E. (2003). "Insulin granule dynamics in pancreatic beta cells". Diabetologia. 46 (8): 1029. doi:10.1007/s00125-003-1153-1. replacement character in |last2= at position 7 (help)
  18. ↑ Ämmälä, C.; Ashcroft, F. M.; Rorsman, P. (1993). "Calcium-independent potentiation of insulin release by cyclic AMP in single β-cells". Nature. 363 (6427): 356. doi:10.1038/363356a0.
  19. ↑ Rorsman, P.; Berggren, P. O.; Bokvist, K.; Ericson, H.; Möhler, H.; Östenson, C. G. R.; Smith, P. A. (1989). "Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channels". Nature. 341 (6239): 233. doi:10.1038/341233a0.
  20. ↑ MacDonald, P. E.; Joseph, J. W.; Rorsman, P. (2005). "Glucose-sensing mechanisms in pancreatic -cells". Philosophical Transactions of the Royal Society B: Biological Sciences. 360 (1464): 2211. doi:10.1098/rstb.2005.1762.
  21. ↑ Gerken, T.; Girard, C. A.; Tung, Y. -C. L.; Webby, C. J.; Saudek, V.; Hewitson, K. S.; Yeo, G. S. H.; McDonough, M. A.; Cunliffe, S.; McNeill, L. A.; Galvanovskis, J.; Rorsman, P.; Robins, P.; Prieur, X.; Coll, A. P.; Ma, M.; Jovanovic, Z.; Farooqi, I. S.; Sedgwick, B.; Barroso, I.; Lindahl, T.; Ponting, C. P.; Ashcroft, F. M.; O'Rahilly, S.; Schofield, C. J. (2007). "The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate-Dependent Nucleic Acid Demethylase". Science. 318 (5855): 1469–1472. doi:10.1126/science.1151710. PMC 2668859Freely accessible. PMID 17991826.
  22. ↑ Patrik Rorsman: Diabetes and Insulin Secretion on YouTube, University of Oxford
  23. ↑ Interview with Patrik Rorsman on YouTube, Scandinavian Physiological Society
  24. ↑ UK Government research grants awarded to Patrik Rorsman, via Research Councils UK
  25. ↑ "Professor Patrik Rorsman FRS FMedSci". London: The Academy of Medical Sciences. Archived from the original on 2014-01-01.
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