Phosphatidylinositol diacylglycerol-lyase

phosphatidylinositol diacylglycerol-lyase
Identifiers
EC number 4.6.1.13
CAS number 37288-19-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
Phosphatidylinositol-specific phospholipase C, image from OPM database

In enzymology, a phosphatidylinositol diacylglycerol-lyase (EC 4.6.1.13) is an enzyme that catalyzes the chemical reaction

1-phosphatidyl-1D-myo-inositol 1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one substrate, 1-phosphatidyl-1D-myo-inositol, and two products, 1D-myo-inositol 1,2-cyclic phosphate and 1,2-diacyl-sn-glycerol.

This enzyme belongs to the family of lyases, specifically the class of phosphorus-oxygen lyases. The systematic name of this enzyme class is 1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming). Other names in common use include monophosphatidylinositol phosphodiesterase, phosphatidylinositol phospholipase C, 1-phosphatidylinositol phosphodiesterase, 1-phosphatidyl-D-myo-inositol inositolphosphohydrolase, (cyclic-phosphate-forming), 1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase, and (1,2-cyclic-phosphate-forming). This enzyme participates in inositol phosphate metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1T6M and 2OR2.

References


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