Phosphopantetheine
Identifiers | |
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2226-71-3 | |
3D model (Jmol) | Interactive image |
ChEBI | CHEBI:4222 |
ChemSpider | 103123 |
DrugBank | DB03912 |
MeSH | phosphopantetheine |
PubChem | 115254 |
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Properties | |
C11H23N2O7PS | |
Molar mass | 358.349 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is ?) | |
Infobox references | |
Phosphopantetheine, also known as 4'-Phosphopantetheine, is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.[1] It is also present in formyltetrahydrofolate dehydrogenase.[2]
Functions
Phosphopantetheine fulfills two demands.
- First, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
- Second, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.
See also
References
- ↑ Elovson J, Vagelos PR (July 1968). "Acyl carrier protein. X. Acyl carrier protein synthetase". J. Biol. Chem. 243 (13): 3603–11. PMID 4872726.
- ↑ Strickland KC, Hoeferlin LA, Oleinik NV, Krupenko NI, Krupenko SA (January 2010). "Acyl carrier protein-specific 4'-phosphopantetheinyl transferase activates 10-formyltetrahydrofolate dehydrogenase". J. Biol. Chem. 285 (3): 1627–33. doi:10.1074/jbc.M109.080556. PMC 2804320. PMID 19933275.
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