Physalaemin

Physalaemin

Identifiers
CAS Number	2507-24-6
ChEMBL	ChEMBL415235
IUPHAR/BPS	2094
MeSH	Physalaemin
PubChem	17268
Properties
Chemical formula	C58H84N14O16S
Molar mass	1265.44 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Physalaemin is a tachykinin peptide obtained from the Physalaemus frog, closely related to substance P. Its structure was first elucidated in 1964.^[1][2]

Like all tachykinins, physalaemin is a sialagogue (increases salivation) and a potent vasodilator with hypotensive effects.^[3]

References

1. Erspaemer V, Anastasi A, Bertaccini G, Cei JM (1964). "Structure and pharmacological actions of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Experientia. 20 (9): 489–90. doi:10.1007/BF02154064. PMID 5857249.
2. Anastasi A, Erspamer V, Cei JM (1964). "Isolation and amino acid sequence of physalaemin, the main active polypeptide of the skin of Physalaemus fuscumaculatus". Arch Biochem Biophys. 108 (2): 341–8. doi:10.1016/0003-9861(64)90395-9. PMID 14240587.
3. Severini C, Improta G, Falconieri-Erspamer G, Salvadori S, Erspamer V (2002). "The tachykinin peptide family". Pharmacol Rev. 54 (2): 285–322. doi:10.1124/pr.54.2.285. PMID 12037144.