Pirenoxine

Pirenoxine
Clinical data
Trade names Catalin
ATCvet code QS01XA91 (WHO)
Identifiers
CAS Number 1043-21-6
PubChem (CID) 4846
ChemSpider 4846
UNII 27L0EP6IZK
ECHA InfoCard 100.012.612
Chemical and physical data
Formula C16H8N2O5
Molar mass 308.24512 g/mol
3D model (Jmol) Interactive image

Pirenoxine (abbreviated PRX, trade name Catalin) is a medication used in the possible treatment and prevention of cataracts. A report in the journal of Inorganic Chemistry showed that in liquid solutions pirenoxine could cause decreased cloudiness of a crystallin solution produced to mimic the environment of the eye. Pirenoxine interacts with selenite or calcium ions that have been proven as factors leading to the formation of lens cataract.[1]

Pirenoxine reduces the cloudiness of the lens solution containing calcium by 38% and reduced the cloudiness of the selenite solution by 11%.

References

  1. Liao, J. H.; Chen, C. S.; Hu, C. C.; Chen, W. T.; Wang, S. P.; Lin, I. L.; Huang, Y. H.; Tsai, M. H.; Wu, T. H.; Huang, F. Y.; Wu, S. H. (2011). "Ditopic Complexation of Selenite Anions or Calcium Cations by Pirenoxine: An Implication for Anti-Cataractogenesis". Inorganic Chemistry. 50 (1): 365–377. doi:10.1021/ic102151p. PMID 21138325.


This article is issued from Wikipedia - version of the 1/30/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.