Pro-opiomelanocortin converting enzyme
| Pro-opiomelanocortin converting enzyme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.23.17 | ||||||||
| CAS number | 80891-34-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pro-opiomelanocortin converting enzyme (EC 3.4.23.17, prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side
This membrane-bound enzyme is isolated from cattle pituitary secretory vesicle.
References
- ↑ Loh, Y.P.; Parish, D.C.; Tuteja, R. (1985). "Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles". J. Biol. Chem. 260: 7194–7205. PMID 2987247.
- ↑ Loh, Y.P. (1986). "Kinetic studies on the processing of human β-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme". J. Biol. Chem. 261: 11949–11955. PMID 3017955.
- ↑ Estivariz, F.E.; Birch, N.P.; Loh, Y.P. (1989). "Generation of Lys-γ3-melanotropin from pro-opiomelanocortin1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme". J. Biol. Chem. 264: 17796–17801. PMID 2553692.
External links
- Pro-opiomelanocortin converting enzyme at the US National Library of Medicine Medical Subject Headings (MeSH)
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