QKI

QKI
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases QKI, Hqk, QK, QK1, QK3, hqkI, KH domain containing, RNA binding
External IDs MGI: 97837 HomoloGene: 11059 GeneCards: QKI
RNA expression pattern




More reference expression data
Orthologs
Species Human Mouse
Entrez

9444

19317

Ensembl

ENSG00000112531

ENSMUSG00000062078

UniProt

Q96PU8

Q9QYS9

RefSeq (mRNA)

NM_001301085
NM_006775
NM_206853
NM_206854
NM_206855

NM_001159516
NM_001159517
NM_021881

RefSeq (protein)

NP_001288014.1
NP_006766.1
NP_996735.1
NP_996736.1
NP_996737.1

NP_001152988.1
NP_001152989.1
NP_068681.1

Location (UCSC) Chr 6: 163.41 – 163.58 Mb Chr 17: 10.21 – 10.32 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Quaking homolog, KH domain RNA binding (mouse), also known as QKI, is a protein which in humans is encoded by the QKI gene.[3][4]

QKI belongs to a family of RNA-binding proteins called STAR proteins for Signal Transduction and Activation of RNA.[5] They have an HNRNPK homology (KH) domain embedded in a 200-amino acid region called the GSG domain. Other members of this family include SAM68 (KHDRBS1) and SF1 .[6] Two more new members are KHDRBS3[7] and KHDRBS2.[8]

The QKI gene is implicated as being important in schizophrenia,[9][10] and QKI controls translation of many oligodendrocyte-related genes.

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. "Entrez Gene: QKI quaking homolog, KH domain RNA binding (mouse)".
  4. Saccomanno L, Loushin C, Jan E, Punkay E, Artzt K, Goodwin EB (October 1999). "The STAR protein QKI-6 is a translational repressor". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12605–10. Bibcode:1999PNAS...9612605S. doi:10.1073/pnas.96.22.12605. PMC 23011Freely accessible. PMID 10535969.
  5. Vernet C, Artzt K (December 1997). "STAR, a gene family involved in signal transduction and activation of RNA". Trends Genet. 13 (12): 479–84. doi:10.1016/S0168-9525(97)01269-9. PMID 9433137.
  6. Chen T, Richard S (August 1998). "Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization". Mol. Cell. Biol. 18 (8): 4863–71. PMC 109071Freely accessible. PMID 9671495.
  7. Venables JP, Vernet C, Chew SL, Elliott DJ, Cowmeadow RB, Wu J, Cooke HJ, Artzt K, Eperon IC (June 1999). "T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis". Hum. Mol. Genet. 8 (6): 959–69. doi:10.1093/hmg/8.6.959. PMID 10332027.
  8. Wang L, Xu J, Zeng L, Ye X, Wu Q, Dai J, Ji C, Gu S, Zhao C, Xie Y, Mao Y (December 2002). "Cloning and characterization of a novel human STAR domain containing cDNA KHDRBS2". Mol. Biol. Rep. 29 (4): 369–75. doi:10.1023/A:1021246109101. PMID 12549823.
  9. Aberg K, Saetre P, Jareborg N, Jazin E (May 2006). "Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 103 (19): 7482–7. Bibcode:2006PNAS..103.7482A. doi:10.1073/pnas.0601213103. PMC 1464365Freely accessible. PMID 16641098.
  10. Haroutunian V, Katsel P, Dracheva S, Davis KL (October 2006). "The human homolog of the QKI gene affected in the severe dysmyelination "quaking" mouse phenotype: downregulated in multiple brain regions in schizophrenia". Am J Psychiatry. 163 (10): 1834–7. doi:10.1176/ajp.2006.163.10.1834. PMID 17012699.

Further reading


This article is issued from Wikipedia - version of the 12/4/2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.