RAB8B

RAB8B
Identifiers
Aliases	RAB8B
External IDs	MGI: 2442982 HomoloGene: 69220 GeneCards: RAB8B
Gene ontology Molecular function • protein binding • nucleotide binding • receptor binding • GTP binding • TPR domain binding • GTPase activity • GDP binding Cellular component • mitochondrion • peroxisomal membrane • cell tip • membrane • phagocytic vesicle membrane • perinuclear region of cytoplasm • plasma membrane • cytoplasmic vesicle • phagocytic vesicle • extracellular exosome Biological process • vesicle docking involved in exocytosis • cilium assembly • protein secretion • positive regulation of cell projection organization • protein import into peroxisome membrane • small GTPase mediated signal transduction • antigen processing and presentation • adherens junction organization • positive regulation of corticotropin secretion • transport • protein transport Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51762	235442
Ensembl	ENSG00000166128	ENSMUSG00000036943
UniProt	Q92930	P61028
RefSeq (mRNA)	NM_016530	NM_173413
RefSeq (protein)	NP_057614.1	NP_775589.1
Location (UCSC)	Chr 15: 63.19 – 63.27 Mb	Chr 9: 66.84 – 66.92 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Ras-related protein Rab-8B is a protein that in humans is encoded by the RAB8B gene.^[3][4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Chen D, Guo J, Gahl WA (Mar 1997). "RAB GTPases expressed in human melanoma cells". Biochim Biophys Acta. 1355 (1): 1–6. doi:10.1016/S0167-4889(96)00169-3. PMID 9030196.
4. Heidrych P, Zimmermann U, Bress A, Pusch CM, Ruth P, Pfister M, Knipper M, Blin N (Nov 2008). "Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form". Hum Mol Genet. 17 (23): 3814–21. doi:10.1093/hmg/ddn279. PMID 18772196.
5. "Entrez Gene: RAB8B RAB8B, member RAS oncogene family".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Lau AS, Mruk DD (2003). "Rab8B GTPase and junction dynamics in the testis.". Endocrinology. 144 (4): 1549–63. doi:10.1210/en.2002-220893. PMID 12639940.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hattula K, Furuhjelm J, Arffman A, Peränen J (2003). "A Rab8-specific GDP/GTP exchange factor is involved in actin remodeling and polarized membrane transport.". Mol. Biol. Cell. 13 (9): 3268–80. doi:10.1091/mbc.E02-03-0143. PMC 124888. PMID 12221131.
• de Bruyn KM, de Rooij J, Wolthuis RM, et al. (2000). "RalGEF2, a pleckstrin homology domain containing guanine nucleotide exchange factor for Ral.". J. Biol. Chem. 275 (38): 29761–6. doi:10.1074/jbc.M001160200. PMID 10889189.
• Armstrong J, Thompson N, Squire JH, et al. (1997). "Identification of a novel member of the Rab8 family from the rat basophilic leukaemia cell line, RBL.2H3.". J. Cell. Sci. 109 (6): 1265–74. PMID 8799816.