RASSF1

RASSF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KZU
Identifiers
Aliases	RASSF1, 123F2, NORE2A, RASSF1A, RDA32, REH3P21, Ras association domain family member 1
External IDs	MGI: 1928386 HomoloGene: 10499 GeneCards: RASSF1
Gene ontology Molecular function • protein N-terminus binding • zinc ion binding • metal ion binding • protein binding • identical protein binding Cellular component • cytoplasm • spindle pole • microtubule cytoskeleton • plasma membrane • spindle • microtubule organizing center • microtubule • cytoskeleton • nucleus Biological process • intracellular signal transduction • protein stabilization • cellular response to DNA damage stimulus • negative regulation of cell cycle arrest • cell cycle arrest • cell cycle • Ras protein signal transduction • positive regulation of protein ubiquitination • signal transduction • regulation of microtubule cytoskeleton organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11186	56289
Ensembl	ENSG00000068028	ENSMUSG00000010067
UniProt	Q9NS23	Q99MK9
RefSeq (mRNA)	NM_001206957 NM_007182 NM_170712 NM_170713 NM_170714 NM_170715 NM_170716 NM_170717	NM_001243748 NM_019713
RefSeq (protein)	NP_001193886.1 NP_009113.3 NP_733830.1 NP_733831.1 NP_733832.1	NP_001230677.1 NP_062687.1
Location (UCSC)	Chr 3: 50.33 – 50.34 Mb	Chr 9: 107.55 – 107.56 Mb
PubMed search	[1]	[2]
Wikidata

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Ras association domain-containing protein 1 is a protein that in humans is encoded by the RASSF1 gene.

Function

This gene encodes a protein similar to the RAS effector proteins. Loss or altered expression of this gene has been associated with the pathogenesis of a variety of cancers, which suggests the tumor suppressor function of this gene. The inactivation of this gene was found to be correlated with the hypermethylation of its CpG-island promoter region. The encoded protein was found to interact with DNA repair protein XPA. The protein was also shown to inhibit the accumulation of cyclin D1, and thus induce cell cycle arrest. Seven alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[3]

Interactions

RASSF1 has been shown to interact with:

• CNKSR1,^[4]
• Death associated protein 6^[5]
• HRAS,^[6]
• MAP1B,^[7]
• MAP1S,^[7][8] and
• RASSF5.^[9]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: RASSF1 Ras association (RalGDS/AF-6) domain family 1".
4. Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A, Mollahan P, Pfeifer GP, Avruch J, Seed B (Jul 2004). "The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death". The Journal of Biological Chemistry. 279 (28): 29247–54. doi:10.1074/jbc.M401699200. PMID 15075335.
5. Song MS, Song SJ, Kim SY, Oh HJ, Lim DS (Jul 2008). "The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex". The EMBO Journal. 27 (13): 1863–74. doi:10.1038/emboj.2008.115. PMC 2486425. PMID 18566590.
6. Vos MD, Ellis CA, Bell A, Birrer MJ, Clark GJ (Nov 2000). "Ras uses the novel tumor suppressor RASSF1 as an effector to mediate apoptosis". The Journal of Biological Chemistry. 275 (46): 35669–72. doi:10.1074/jbc.C000463200. PMID 10998413.
7. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Research. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.
8. Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Research. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
9. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.