RFWD2

RFWD2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases RFWD2, COP1, RNF200, ring finger and WD repeat domain 2
External IDs MGI: 1347046 HomoloGene: 115565 GeneCards: RFWD2
Orthologs
Species Human Mouse
Entrez

64326

26374

Ensembl

ENSG00000143207

ENSMUSG00000040782

UniProt

Q8NHY2

Q9R1A8

RefSeq (mRNA)

NM_001001740
NM_001286644
NM_022457

NM_011931

RefSeq (protein)

NP_001001740.1
NP_001273573.1
NP_071902.2

NP_036061.1

Location (UCSC) Chr 1: 175.94 – 176.21 Mb Chr 1: 159.23 – 159.35 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.[3][4]

Interactions

RFWD2 has been shown to interact with C-jun.[5][6]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Wang H, Kang D, Deng XW, Wei N (Sep 1999). "Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1". Curr Biol. 9 (13): 711–4. doi:10.1016/S0960-9822(99)80314-5. PMID 10395541.
  4. "Entrez Gene: RFWD2 ring finger and WD repeat domain 2".
  5. Wertz IE, O'Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (Feb 2004). "Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase". Science. 303 (5662): 1371–4. doi:10.1126/science.1093549. PMID 14739464.
  6. Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (May 2003). "Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity". J. Biol. Chem. 278 (22): 19682–90. doi:10.1074/jbc.M212681200. PMID 12615916.

Further reading


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