ROBO2

ROBO2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UEM, 1UJT, 2EDJ
Identifiers
Aliases	ROBO2, SAX3, roundabout guidance receptor 2
External IDs	MGI: 1890110 HomoloGene: 43188 GeneCards: ROBO2
Genetically Related Diseases
periodontitis[1]
Gene ontology Molecular function • protein binding • identical protein binding • axon guidance receptor activity Cellular component • integral component of membrane • membrane • cell surface • axolemma • extracellular exosome Biological process • cell differentiation • ureteric bud development • kidney development • negative regulation of synapse assembly • Roundabout signaling pathway • positive regulation of axonogenesis • nervous system development • multicellular organism development • chemotaxis • central nervous system development • cellular response to hormone stimulus • olfactory bulb interneuron development • apoptotic process involved in luteolysis • negative regulation of negative chemotaxis • axon midline choice point recognition • metanephros development • homophilic cell adhesion via plasma membrane adhesion molecules • retinal ganglion cell axon guidance • brain development • spinal cord development • axon guidance Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6092	268902
Ensembl	ENSG00000185008	ENSMUSG00000052516
UniProt	Q9HCK4	Q7TPD3
RefSeq (mRNA)	NM_001128929 NM_001290039 NM_001290040 NM_001290065 NM_002942	NM_175549
RefSeq (protein)	NP_001122401.1 NP_001276968.1 NP_001276969.1 NP_001276994.1 NP_002933.1	n/a
Location (UCSC)	Chr 3: 75.91 – 77.65 Mb	Chr 16: 73.89 – 74.41 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^[4][5]

References

1. "Diseases that are genetically associated with ROBO2 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell. 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045.
5. "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)".

Further reading

• Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.". Cell. 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268.
• Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons.". Neuron. 22 (3): 463–73. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527.
• Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
• Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.". J. Neurosci. 21 (12): 4281–9. PMID 11404413.
• Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain.". J. Comp. Neurol. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hivert B, Liu Z, Chuang CY, et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.". Mol. Cell. Neurosci. 21 (4): 534–45. doi:10.1006/mcne.2002.1193. PMID 12504588.
• Grieshammer U, Le M, Plump AS, et al. (2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.". Dev. Cell. 6 (5): 709–17. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yue Y, Grossmann B, Galetzka D, et al. (2007). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.". Genomics. 88 (6): 772–8. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
• Lu W, van Eerde AM, Fan X, et al. (2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.". Am. J. Hum. Genet. 80 (4): 616–32. doi:10.1086/512735. PMC 1852714. PMID 17357069.