RRAGC

RRAGC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LLU
Identifiers
Aliases	RRAGC, GTR2, RAGC, TIB929, Ras related GTP binding C
External IDs	MGI: 1858751 HomoloGene: 39141 GeneCards: RRAGC
Gene ontology Molecular function • nucleotide binding • GDP binding • GTP binding • protein binding • GTPase activity • protein heterodimerization activity • magnesium ion binding Cellular component • cytoplasm • cytosol • intracellular membrane-bounded organelle • Gtr1-Gtr2 GTPase complex • lysosome • nucleus • EGO complex Biological process • regulation of TOR signaling • small GTPase mediated signal transduction • cellular response to amino acid starvation • transcription, DNA-templated • cellular protein localization • cell growth • cell cycle arrest • RNA splicing • cellular response to amino acid stimulus • macroautophagy • apoptotic process • regulation of TORC1 signaling • regulation of autophagy • response to amino acid • positive regulation of TOR signaling Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	64121	54170
Ensembl	ENSG00000116954	ENSMUSG00000028646
UniProt	Q9HB90	Q99K70
RefSeq (mRNA)	NM_022157 NM_001271851	NM_017475
RefSeq (protein)	NP_001258780.1 NP_071440.1	NP_059503.2
Location (UCSC)	Chr 1: 38.84 – 38.86 Mb	Chr 4: 123.92 – 123.94 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Ras-related GTP binding C, also known as RRAGC, is a protein which in humans is encoded by the RRAGC gene.^[3][4]

RRAGC is a monomeric guanine nucleotide-binding protein, or G protein. By binding GTP or GDP, small G proteins act as molecular switches in numerous cell processes and signaling pathways.^[3]

Interactions

RRAGC has been shown to interact with RRAGA.^[4][5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: RRAGC Ras-related GTP binding C".
4. Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.
5. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

Further reading

• Horwitz MS (Jan 2001). "Adenovirus immunoregulatory genes and their cellular targets". Virology. 279 (1): 1–8. doi:10.1006/viro.2000.0738. PMID 11145883.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Sekiguchi T, Todaka Y, Wang Y, Hirose E, Nakashima N, Nishimoto T (Feb 2004). "A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D". The Journal of Biological Chemistry. 279 (9): 8343–50. doi:10.1074/jbc.M305935200. PMID 14660641.
• Sekiguchi T, Hirose E, Nakashima N, Ii M, Nishimoto T (Mar 2001). "Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B". The Journal of Biological Chemistry. 276 (10): 7246–57. doi:10.1074/jbc.M004389200. PMID 11073942.