RSPO2

RSPO2
Identifiers
Aliases	RSPO2, CRISTIN2, R-spondin 2
External IDs	MGI: 1922667 HomoloGene: 18235 GeneCards: RSPO2
Gene ontology Molecular function • heparin binding • receptor binding • protein binding Cellular component • extracellular region • cell surface Biological process • positive regulation of canonical Wnt signaling pathway • positive regulation of Wnt signaling pathway • bone mineralization • lung growth • dopaminergic neuron differentiation • epithelial tube branching involved in lung morphogenesis • Wnt signaling pathway • embryonic forelimb morphogenesis • negative regulation of odontogenesis of dentin-containing tooth • osteoblast differentiation • response to stimulus • trachea cartilage morphogenesis • embryonic hindlimb morphogenesis Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	340419	239405
Ensembl	ENSG00000147655	ENSMUSG00000051920
UniProt	Q6UXX9	Q8BFU0
RefSeq (mRNA)	NM_001282863 NM_178565 NM_001317942	NM_172815
RefSeq (protein)	NP_001269792.1 NP_848660.3 NP_001304871.1	NP_766403.1
Location (UCSC)	Chr 8: 107.9 – 108.08 Mb	Chr 15: 43.02 – 43.17 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

R-spondin 2 also known as roof plate-specific spondin-2 is a protein that in humans that is encoded by the RSPO2 gene.^[3]

R-spondin 2 synergizes with Wnt to activate beta-catenin.^[4][5] RSPO2 has been proposed to regulate craniofacial patterning and morphogenesis within pharyngeal arch 1 through ectoderm-mesenchyme signaling via the endothelin-Dlx5/6 pathway.^[6]

In dogs, the Rspo2 gene determines hair growth.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: R-spondin 2".
4. Kim KA, Zhao J, Andarmani S, Kakitani M, Oshima T, Binnerts ME, Abo A, Tomizuka K, Funk WD (January 2006). "R-Spondin proteins: a novel link to beta-catenin activation". Cell Cycle. 5 (1): 23–6. doi:10.4161/cc.5.1.2305. PMID 16357527.
5. Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W (October 2004). "R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis". Dev. Cell. 7 (4): 525–34. doi:10.1016/j.devcel.2004.07.019. PMID 15469841.
6. Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK (2011). "The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal–mesenchymal interaction". Developmental Biology. 352 (1): 1–13. doi:10.1016/j.ydbio.2011.01.004. PMC 3089906. PMID 21237142.
7. Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA (October 2009). "Coat variation in the domestic dog is governed by variants in three genes". Science. 326 (5949): 150–3. doi:10.1126/science.1177808. PMC 2897713. PMID 19713490.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.