Rozalyn Anderson

Rozalyn Anderson
Institutions University of Wisconsin
Alma mater Trinity College and University college, Dublin, Ireland
Known for Caloric restriction longevity studies in primates
Website
www.medicine.wisc.edu/geriatrics/andersonlabmain

Rozalyn (Roz) Anderson is an assistant professor at the University of Wisconsin School of Medicine and Public Health. She studies aging and caloric restriction in primates.[1]

Education

Anderson received her bachelor's degree from Trinity College, Dublin and her Ph.D. in biochemistry from University College Dublin. In 2000 she moved to Harvard Medical School, Boston, Massachusetts for a post-doctoral fellowship with David Sinclair, where she studied caloric restriction and aging in yeast. She began studying mammalian aging during a second post-doctoral fellowship with Richard Weindruch at the University of Wisconsin Institute on Aging and as an assistant scientist at the Wisconsin National Primate Research Center. She became an assistant professor at the University of Wisconsin in 2010 in the Department of Medicine in the Division of Geriatrics and Gerontology .[1][2] Since 2014, Anderson has also been affiliated with the Division of Endocrinology, Diabetes and Metabolism.[3]

Research

In the Sinclair laboratory at Harvard Medical School, Anderson researched the regulation of the lifespan by calorie restriction in yeast, demonstrating that lifespan could be extended by genetic manipulation of the NAD+ salvage pathway,[4][5] and for the first time demonstrated regulation of NAD+ by calorie restriction.[6] Anderson's work forms the foundation of the NAD World hypothesis, a "systemic regulatory mechanism that fundamentally connects metabolism and aging".[7]

Anderson worked as part of the University of Wisconsin team that demonstrated that caloric restriction has a beneficial effect in rhesus monkeys, improves survival, and lowers the incidence of diseases including diabetes, cancer, and cardiovascular disease over the course of nearly three decades.[8][9][10][11] She continues to study caloric restriction, focusing on primate skeletal muscle, white adipose tissue, inflammation, mitochondrial dysfunction, and metabolic regulators of cancer growth.[2]

In a 2014 interview discussing the different results of the National Institute of Aging and University of Wisconsin rhesus monkey caloric restriction studies, Anderson points out that due to the experimental setup, both the control and experimental groups were calorie restricted to some degree, which explains why no significant improvement was found in the experimental group. She also points out that the two studies are more informative due to their differing designs than if they had been performed identically.[12] [13]

In 2013, Anderson won the Nathan Shock New Investigator Award from the Gerontological Society of America.[14][15]

Anderson is a deputy editor of The Journals of Gerontology: Series A.[16]

References

  1. 1 2 "University of Wisconsin - Madison Institute on Aging, Madison, Wisconsin". aging.wisc.edu. Retrieved 12 August 2014.
  2. 1 2 "Rozalyn Anderson's Laboratory | University Of Wisconsin - Department of Medicine". medicine.wisc.edu. Retrieved 12 August 2014.
  3. ↑ "Meet Our Faculty and Staff". Retrieved 2015-09-12.
  4. ↑ Anderson, Rozalyn M.; Bitterman, Kevin J.; Wood, Jason G.; Medvedik, Oliver; Cohen, Haim; Lin, Stephen S.; Manchester, Jill K.; Gordon, Jeffrey I.; Sinclair, David A. (2002-05-24). "Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels". The Journal of Biological Chemistry. 277 (21): 18881–18890. doi:10.1074/jbc.M111773200. ISSN 0021-9258. PMID 11884393.
  5. ↑ Anderson, Rozalyn M.; Bitterman, Kevin J.; Wood, Jason G.; Medvedik, Oliver; Sinclair, David A. (2003-05-08). "Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae". Nature. 423 (6936): 181–185. doi:10.1038/nature01578. ISSN 0028-0836. PMID 12736687.
  6. ↑ Anderson, Rozalyn M.; Latorre-Esteves, Magda; Neves, Ana Rute; Lavu, Siva; Medvedik, Oliver; Taylor, Christopher; Howitz, Konrad T.; Santos, Helena; Sinclair, David A. (2003-12-19). "Yeast life-span extension by calorie restriction is independent of NAD fluctuation". Science. 302 (5653): 2124–2126. doi:10.1126/science.1088697. ISSN 1095-9203. PMID 14605207.
  7. ↑ Imai, Shin-Ichiro (2009-01-01). "The NAD World: a new systemic regulatory network for metabolism and aging--Sirt1, systemic NAD biosynthesis, and their importance". Cell Biochemistry and Biophysics. 53 (2): 65–74. doi:10.1007/s12013-008-9041-4. ISSN 1559-0283. PMC 2734380Freely accessible. PMID 19130305.
  8. ↑ Colman RJ, Anderson RM, Johnson SC; et al. (2009). "Caloric restriction delays disease onset and mortality in rhesus monkeys". Science. 325 (5937): 201–4. Bibcode:2009Sci...325..201C. doi:10.1126/science.1173635. PMC 2812811Freely accessible. PMID 19590001.
  9. ↑ Colman RJ; Beasley TM; Kemnitz JW; Johnson SC; Weindruch R; Anderson RM (Apr 1, 2014). "Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys". Nature Communications. 5: 3557. Bibcode:2014NatCo...5E3557C. doi:10.1038/ncomms4557. PMC 3988801Freely accessible. PMID 24691430. Retrieved 30 April 2014.
  10. ↑ Anderson, R. M.; Shanmuganayagam, D.; Weindruch, R. (2009). "Caloric Restriction and Aging: Studies in Mice and Monkeys". Toxicologic Pathology. 37 (1): 47–51. doi:10.1177/0192623308329476. PMID 19075044.
  11. ↑ Rezzi, Serge; Martin, François-Pierre J.; Shanmuganayagam, Dhanansayan; Colman, Ricki J.; Nicholson, Jeremy K.; Weindruch, Richard (2009). "Metabolic shifts due to long-term caloric restriction revealed in nonhuman primates". Experimental Gerontology. 44 (5): 356–62. doi:10.1016/j.exger.2009.02.008. PMC 2822382Freely accessible. PMID 19264119.
  12. ↑ "The New York Times". nytimes.com. Retrieved 12 August 2014.
  13. ↑ "The New York Times". nytimes.com. Retrieved 12 August 2014.
  14. ↑ Health, University of Wisconsin School of Medicine and Public. "UWSMPH". UW School of Medicine and Public Health. Retrieved 2015-09-12.
  15. ↑ Rogers, Anthony. "Awardees - Nathan Shock Award". prod.geron.org. Retrieved 2015-09-12.
  16. ↑ "Oxford Journals | Medicine & Health & Science & Mathematics | The Journals of Gerontology: Series A | Editorial Board - Biological Sciences". www.oxfordjournals.org. Retrieved 2015-09-12.
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