SERPINI2

SERPINI2
Identifiers
Aliases	SERPINI2, MEPI, PANCPIN, PI14, TSA2004, serpin family I member 2
External IDs	MGI: 1915181 HomoloGene: 21248 GeneCards: SERPINI2
Gene ontology Molecular function • peptidase inhibitor activity • protein binding • serine-type endopeptidase inhibitor activity Cellular component • extracellular fluid • extracellular region • extracellular exosome Biological process • movement of cell or subcellular component • negative regulation of peptidase activity • negative regulation of endopeptidase activity Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5276	67931
Ensembl	ENSG00000114204	ENSMUSG00000034139
UniProt	O75830	Q9JK88
RefSeq (mRNA)	NM_006217 NM_001012303	NM_026460
RefSeq (protein)	NP_001012303.1 NP_006208.1	NP_080736.2
Location (UCSC)	Chr 3: 167.44 – 167.48 Mb	Chr 3: 75.24 – 75.27 Mb
PubMed search	[1]	[2]
Wikidata

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Serpin I2 is a protein that in humans is encoded by the SERPINI2 gene.^[3][4]

The protein encoded by this gene is a member of the serine protease inhibitor (serpin) superfamily made up of proteins which play central roles in the regulation of a wide variety of physiological processes, including coagulation, fibrinolysis, development, malignancy and inflammation. The gene product may have a role in a growth-control, possibly growth-suppressing pathway and, when impaired, may be involved in pancreatic carcinogenesis. The protein is a member of the plasminogen activator inhibitor-1 family, a subset of the serpin superfamily whose members act as tissue-specific tPA inhibitors. Two alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene.^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Ozaki K; Nagata M; Suzuki M; Fujiwara T; Miyoshi Y; Ishikawa O; Ohigashi H; Imaoka S; Takahashi E; Nakamura Y (Jul 1998). "Isolation and characterization of a novel human pancreas-specific gene, pancpin, that is down-regulated in pancreatic cancer cells". Genes Chromosomes Cancer. 22 (3): 179–85. doi:10.1002/(SICI)1098-2264(199807)22:3<179::AID-GCC3>3.0.CO;2-T. PMID 9624529.
4. "Entrez Gene: SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2".

Further reading

• Maruyama K; Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Xiao G, Liu YE, Gentz R, et al. (1999). "Suppression of breast cancer growth and metastasis by a serpin myoepithelium-derived serine proteinase inhibitor expressed in the mammary myoepithelial cells". Proc. Natl. Acad. Sci. U.S.A. 96 (7): 3700–5. doi:10.1073/pnas.96.7.3700. PMC 22357. PMID 10097100.
• Chang WS, Chang NT, Lin SC, et al. (2000). "Tissue-specific cancer-related serpin gene cluster at human chromosome band 3q26". Genes Chromosomes Cancer. 29 (3): 240–55. doi:10.1002/1098-2264(2000)9999:9999<::AID-GCC1029>3.0.CO;2-A. PMID 10992299.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.026