SFRS12

SREK1
Identifiers
Aliases	SREK1, SFRS12, SRrp508, SRrp86, splicing regulatory glutamic acid/lysine-rich protein 1, splicing regulatory glutamic acid and lysine rich protein 1
External IDs	MGI: 2145245 HomoloGene: 10581 GeneCards: SREK1
Gene ontology Molecular function • nucleotide binding • poly(A) RNA binding • protein binding • nucleic acid binding Cellular component • spliceosomal complex • nucleus • nucleoplasm Biological process • mRNA processing • RNA splicing • regulation of alternative mRNA splicing, via spliceosome Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	140890	218543
Ensembl	ENSG00000153914	ENSMUSG00000032621
UniProt	Q8WXA9	Q8BZX4
RefSeq (mRNA)	NM_001077199 NM_001270492 NM_001270493 NM_139168 NM_001323527 NM_001323529 NM_001323533 NM_001323534 NM_001323535	NM_172592
RefSeq (protein)	NP_001070667.1 NP_001257421.1 NP_631907.1 NP_001310456.1	NP_766180.1
Location (UCSC)	Chr 5: 66.14 – 66.18 Mb	Chr 13: 103.74 – 103.76 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

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Splicing factor, arginine/serine-rich 12 is a protein that in humans is encoded by the SFRS12 gene.^[3][4]

SFRS12 belongs to the superfamily of serine/arginine-rich (SR) splicing factors. It modulates splice site selection by regulating the activities of other SR proteins (Barnard et al., 2002).[supplied by OMIM]^[4]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Zhang DL, Sun XJ, Ling LJ, Chen RS, Ma DL (Jun 2002). "[Molecular cloning, characterization, chromosomal assignment, genomic organization and verification of SFRS12(SRrp508), a novel member of human SR protein superfamily and a human homolog of rat SRrp86]". Yi Chuan Xue Bao. 29 (5): 377–83. PMID 12043562.
4. "Entrez Gene: SFRS12 splicing factor, arginine/serine-rich 12".

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Heese K, Fujita M, Akatsu H, et al. (2005). "The splicing regulatory protein p18SRP is down-regulated in Alzheimer's disease brain.". J. Mol. Neurosci. 24 (2): 269–76. doi:10.1385/JMN:24:2:269. PMID 15456940.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of alternative splicing by SRrp86 and its interacting proteins.". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Peng R, Dye BT, Pérez I, et al. (2002). "PSF and p54nrb bind a conserved stem in U5 snRNA.". RNA. 8 (10): 1334–47. doi:10.1017/S1355838202022070. PMC 1370341. PMID 12403470.
• Li J, Barnard DC, Patton JG (2002). "A unique glutamic acid-lysine (EK) domain acts as a splicing inhibitor.". J. Biol. Chem. 277 (42): 39485–92. doi:10.1074/jbc.M201784200. PMID 12183448.
• Rappsilber J, Ryder U, Lamond AI, Mann M (2002). "Large-scale proteomic analysis of the human spliceosome.". Genome Res. 12 (8): 1231–45. doi:10.1101/gr.473902. PMC 186633. PMID 12176931.
• Barnard DC, Li J, Peng R, Patton JG (2002). "Regulation of alternative splicing by SRrp86 through coactivation and repression of specific SR proteins.". RNA. 8 (4): 526–33. doi:10.1017/S1355838202029928. PMC 1370273. PMID 11991645.
• Barnard DC, Patton JG (2000). "Identification and characterization of a novel serine-arginine-rich splicing regulatory protein.". Mol. Cell. Biol. 20 (9): 3049–57. doi:10.1128/MCB.20.9.3049-3057.2000. PMC 85584. PMID 10757789.