SHB (gene)

SHB
Identifiers
Aliases	SHB, bA3J10.2, SH2 domain containing adaptor protein B
External IDs	MGI: 98294 HomoloGene: 74458 GeneCards: SHB
Gene ontology Molecular function • protein binding • SH3/SH2 adaptor activity • glycoprotein binding Cellular component • cytoplasm • cytosol • plasma membrane • membrane Biological process • multicellular organism development • cell differentiation • vascular endothelial growth factor receptor signaling pathway • angiogenesis • signal transduction • apoptotic process • hematopoietic stem cell proliferation • negative regulation of protein kinase activity • B cell proliferation • hemopoiesis • negative regulation of oocyte maturation • positive regulation of mitotic cell cycle • positive regulation of T-helper cell differentiation • positive regulation of signal transduction • blood vessel development • T cell receptor signaling pathway • blood vessel morphogenesis Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6461	230126
Ensembl	ENSG00000107338	ENSMUSG00000044813
UniProt	Q15464	Q6PD21
RefSeq (mRNA)	NM_003028	NM_001033306
RefSeq (protein)	NP_003019.2	NP_001028478.1
Location (UCSC)	Chr 9: 37.92 – 38.07 Mb	Chr 4: 45.42 – 45.53 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

SH2 domain-containing adapter protein B is a protein that in humans is encoded by the SHB gene.^[3][4]

Interactions

SHB (gene) has been shown to interact with:

• EPS8,^[5]
• Fibroblast growth factor receptor 1,^[5]
• Linker of activated T cells,^[6][7]
• Lymphocyte cytosolic protein 2,^[7]
• PIK3R1,^[5]
• Src,^[5]
• VAV1,^[7] and
• ZAP-70.^[7]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Yulug IG, Hillermann R, Fisher EM (Dec 1994). "The SHB adaptor protein maps to human chromosome 9". Genomics. 24 (3): 615–7. doi:10.1006/geno.1994.1681. PMID 7713524.
4. "Entrez Gene: SHB Src homology 2 domain containing adaptor protein B".
5. Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.
6. Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
7. Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry / FEBS. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.

Further reading

• Karlsson T, Songyang Z, Landgren E, Lavergne C, Di Fiore PP, Anafi M, Pawson T, Cantley LC, Claesson-Welsh L, Welsh M (Apr 1995). "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475–83. PMID 7537362.
• Welsh M, Mares J, Karlsson T, Lavergne C, Bréant B, Claesson-Welsh L (Jan 1994). "Shb is a ubiquitously expressed Src homology 2 protein". Oncogene. 9 (1): 19–27. PMID 8302579.
• Karlsson T, Welsh M (Sep 1996). "Apoptosis of NIH3T3 cells overexpressing the Src homology 2 domain protein Shb". Oncogene. 13 (5): 955–61. PMID 8806685.
• Welsh M, Songyang Z, Frantz JD, Trüb T, Reedquist KA, Karlsson T, Miyazaki M, Cantley LC, Band H, Shoelson SE (Feb 1998). "Stimulation through the T cell receptor leads to interactions between SHB and several signaling proteins". Oncogene. 16 (7): 891–901. doi:10.1038/sj.onc.1201607. PMID 9484780.
• Karlsson T, Kullander K, Welsh M (Sep 1998). "The Src homology 2 domain protein Shb transmits basic fibroblast growth factor- and nerve growth factor-dependent differentiation signals in PC12 cells". Cell Growth & Differentiation. 9 (9): 757–66. PMID 9751119.
• Lindholm CK, Gylfe E, Zhang W, Samelson LE, Welsh M (Sep 1999). "Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells". The Journal of Biological Chemistry. 274 (39): 28050–7. doi:10.1074/jbc.274.39.28050. PMID 10488157.
• Dixelius J, Larsson H, Sasaki T, Holmqvist K, Lu L, Engström A, Timpl R, Welsh M, Claesson-Welsh L (Jun 2000). "Endostatin-induced tyrosine kinase signaling through the Shb adaptor protein regulates endothelial cell apoptosis". Blood. 95 (11): 3403–11. PMID 10828022.
• Hooshmand-Rad R, Lu L, Heldin CH, Claesson-Welsh L, Welsh M (Jun 2000). "Platelet-derived growth factor-mediated signaling through the Shb adaptor protein: effects on cytoskeletal organization". Experimental Cell Research. 257 (2): 245–54. doi:10.1006/excr.2000.4896. PMID 10837138.
• Lu L, Annerén C, Reedquist KA, Bos JL, Welsh M (Sep 2000). "NGF-Dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway". Experimental Cell Research. 259 (2): 370–7. doi:10.1006/excr.2000.4984. PMID 10964504.
• Diakonova M, Gunter DR, Herrington J, Carter-Su C (Mar 2002). "SH2-Bbeta is a Rac-binding protein that regulates cell motility". The Journal of Biological Chemistry. 277 (12): 10669–77. doi:10.1074/jbc.M111138200. PMID 11786545.
• Lindholm CK, Henriksson ML, Hallberg B, Welsh M (Jul 2002). "Shb links SLP-76 and Vav with the CD3 complex in Jurkat T cells". European Journal of Biochemistry / FEBS. 269 (13): 3279–88. doi:10.1046/j.1432-1033.2002.03008.x. PMID 12084069.
• Cross MJ, Lu L, Magnusson P, Nyqvist D, Holmqvist K, Welsh M, Claesson-Welsh L (Aug 2002). "The Shb adaptor protein binds to tyrosine 766 in the FGFR-1 and regulates the Ras/MEK/MAPK pathway via FRS2 phosphorylation in endothelial cells". Molecular Biology of the Cell. 13 (8): 2881–93. doi:10.1091/mbc.E02-02-0103. PMC 117949. PMID 12181353.
• Lindholm CK (Aug 2002). "IL-2 receptor signaling through the Shb adapter protein in T and NK cells". Biochemical and Biophysical Research Communications. 296 (4): 929–36. doi:10.1016/S0006-291X(02)02016-8. PMID 12200137.
• Holmqvist K, Cross M, Riley D, Welsh M (Feb 2003). "The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells". Cellular Signalling. 15 (2): 171–9. doi:10.1016/S0898-6568(02)00076-1. PMID 12464388.
• Welsh N, Makeeva N, Welsh M (Nov 2002). "Overexpression of the Shb SH2 domain-protein in insulin-producing cells leads to altered signaling through the IRS-1 and IRS-2 proteins". Molecular Medicine. 8 (11): 695–704. PMC 2039954. PMID 12520086.
• Holmqvist K, Cross MJ, Rolny C, Hägerkvist R, Rahimi N, Matsumoto T, Claesson-Welsh L, Welsh M (May 2004). "The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration". The Journal of Biological Chemistry. 279 (21): 22267–75. doi:10.1074/jbc.M312729200. PMID 15026417.