SLIT1

SLIT1
Identifiers
Aliases	SLIT1, MEGF4, SLIL1, SLIT-1, SLIT3, slit guidance ligand 1
External IDs	MGI: 1315203 HomoloGene: 2302 GeneCards: SLIT1
Genetically Related Diseases
obesity[1]
Gene ontology Molecular function • calcium ion binding • heparin binding • Roundabout binding Cellular component • cell • proteinaceous extracellular matrix • extracellular fluid • extracellular region Biological process • chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration • cell differentiation • neuron projection morphogenesis • dorsal/ventral axon guidance • negative chemotaxis • axonogenesis • negative regulation of synapse assembly • Roundabout signaling pathway • nervous system development • telencephalon cell migration • regulation of axonogenesis • multicellular organism development • forebrain morphogenesis • tangential migration from the subventricular zone to the olfactory bulb • establishment of nucleus localization • olfactory bulb development • motor neuron axon guidance • axon extension involved in axon guidance • retinal ganglion cell axon guidance • axon guidance Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	6585	20562
Ensembl	ENSG00000187122	ENSMUSG00000025020
UniProt	O75093	Q80TR4
RefSeq (mRNA)	NM_003061	NM_015748
RefSeq (protein)	NP_003052.2	NP_056563.2
Location (UCSC)	Chr 10: 97 – 97.19 Mb	Chr 19: 41.6 – 41.74 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.^[4][5][6]

References

1. "Diseases that are genetically associated with SLIT1 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Nakayama M; Nakajima D; Nagase T; Nomura N; Seki N; Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
5. Itoh A; Miyabayashi T; Ohno M; Sakano S (Feb 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res. 62 (2): 175–186. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
6. "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)".

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Wong K; Park HT; Wu JY; Rao Y (2003). "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes". Curr. Opin. Genet. Dev. 12 (5): 583–591. doi:10.1016/S0959-437X(02)00343-X. PMID 12200164.
• Liang Y, Annan RS, Carr SA, et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. 274 (25): 17885–17892. doi:10.1074/jbc.274.25.17885. PMID 10364234.
• Wu W, Wong K, Chen J, et al. (1999). "Directional guidance of neuronal migration in the olfactory system by the protein Slit". Nature. 400 (6742): 331–336. doi:10.1038/22477. PMC 2041931. PMID 10432110.
• Yuan W, Zhou L, Chen JH, et al. (1999). "The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance". Dev. Biol. 212 (2): 290–306. doi:10.1006/dbio.1999.9371. PMID 10433822.
• Little M, Rumballe B, Georgas K, et al. (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". Int. J. Dev. Biol. 46 (4): 385–91. PMID 12141424.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hammond R, Vivancos V, Naeem A, et al. (2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain". Development. 132 (20): 4483–4495. doi:10.1242/dev.02038. PMID 16162649.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
• Lin L; Isacson O (2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits". Stem Cells. 24 (11): 2504–2513. doi:10.1634/stemcells.2006-0119. PMC 2613222. PMID 16840550.
• Hussain SA, Piper M, Fukuhara N, et al. (2007). "A molecular mechanism for the heparan sulfate dependence of slit-robo signaling". J. Biol. Chem. 281 (51): 39693–39698. doi:10.1074/jbc.M609384200. PMID 17062560.