SMARCD3

SMARCD3
Identifiers
Aliases	SMARCD3, BAF60C, CRACD3, Rsc6p, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
External IDs	MGI: 1914243 HomoloGene: 2314 GeneCards: SMARCD3
Gene ontology Molecular function • transcription coactivator activity • transcription factor binding • chromatin binding • nuclear hormone receptor binding • protein binding • ligand-dependent nuclear receptor binding • ligand-dependent nuclear receptor transcription coactivator activity • receptor binding Cellular component • cytoplasm • nBAF complex • SWI/SNF complex • nucleoplasm • npBAF complex • nuclear chromatin • BAF-type complex • nucleus Biological process • positive regulation of neuroblast proliferation • chromatin remodeling • regulation of transcription, DNA-templated • cellular lipid metabolic process • cardiac right ventricle formation • regulation of transcription from RNA polymerase II promoter • heart morphogenesis • transcription, DNA-templated • nervous system development • positive regulation of transcription, DNA-templated • muscle cell differentiation • nucleosome disassembly • positive regulation of smooth muscle cell differentiation • positive regulation of G2/M transition of mitotic cell cycle • secondary heart field specification • regulation of protein binding • neural retina development • covalent chromatin modification Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6604	66993
Ensembl	ENSG00000082014	ENSMUSG00000028949
UniProt	Q6STE5	Q6P9Z1
RefSeq (mRNA)	NM_001003801 NM_001003802 NM_003078	NM_025891
RefSeq (protein)	NP_001003801.1 NP_001003802.1 NP_003069.2	NP_080167.3
Location (UCSC)	Chr 7: 151.24 – 151.28 Mb	Chr 5: 24.59 – 24.62 Mb
PubMed search	[1]	[2]
Wikidata

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SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is encoded by the SMARCD3 gene.^[3][4][5]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene.^[5] Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or differentiation during development and disease.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Wang W; Xue Y; Zhou S; Kuo A; Cairns BR; Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev. 10 (17): 2117–2130. doi:10.1101/gad.10.17.2117. PMID 8804307.
4. Ring HZ; Vameghi-Meyers V; Wang W; Crabtree GR; Francke U (Sep 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–143. doi:10.1006/geno.1998.5343. PMID 9693044.
5. "Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3".
6. Puri, P. L.; Mercola, M (2012). "BAF60 A, B, and Cs of muscle determination and renewal". Genes & Development. 26 (24): 2673–83. doi:10.1101/gad.207415.112. PMC 3533072. PMID 23222103.

Further reading

• Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581.
• Shanahan F, Seghezzi W, Parry D, et al. (1999). "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Mol. Cell. Biol. 19 (2): 1460–9. doi:10.1128/mcb.19.2.1460. PMC 116074. PMID 9891079.
• Barker N, Hurlstone A, Musisi H, et al. (2001). "The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation". EMBO J. 20 (17): 4935–4943. doi:10.1093/emboj/20.17.4935. PMC 125268. PMID 11532957.
• Otsuki T, Furukawa Y, Ikeda K, et al. (2002). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. 10 (23): 2651–2660. doi:10.1093/hmg/10.23.2651. PMID 11726552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948.
• Nagaraja GM; Kandpal RP (2004). "Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins". Biochem. Biophys. Res. Commun. 313 (3): 654–665. doi:10.1016/j.bbrc.2003.12.001. PMID 14697242.
• Debril MB, Gelman L, Fayard E, et al. (2004). "Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit". J. Biol. Chem. 279 (16): 16677–16686. doi:10.1074/jbc.M312288200. PMID 14701856.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mahmoudi T, Parra M, Vries RG, et al. (2006). "The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter". J. Biol. Chem. 281 (29): 19960–19968. doi:10.1074/jbc.M603336200. PMID 16687403.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.