SOCS4

SOCS4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2IZV
Identifiers
Aliases	SOCS4, SOCS7, suppressor of cytokine signaling 4
External IDs	MGI: 1914546 HomoloGene: 15442 GeneCards: SOCS4
Gene ontology Molecular function • protein kinase inhibitor activity • protein binding Cellular component • cytoplasm Biological process • negative regulation of epidermal growth factor-activated receptor activity • regulation of growth • negative regulation of signal transduction • intracellular signal transduction • positive regulation of proteasomal ubiquitin-dependent protein catabolic process • protein ubiquitination • cytokine-mediated signaling pathway • negative regulation of JAK-STAT cascade Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	122809	67296
Ensembl	ENSG00000180008	ENSMUSG00000048379
UniProt	Q8WXH5	Q91ZA6
RefSeq (mRNA)	NM_080867 NM_199421	NM_080843
RefSeq (protein)	NP_543143.1 NP_955453.1	NP_543119.2
Location (UCSC)	Chr 14: 55.03 – 55.05 Mb	Chr 14: 47.28 – 47.3 Mb
PubMed search	[1]	[2]
Wikidata

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Suppressor of cytokine signaling 4 is a protein that in humans is encoded by the SOCS4 gene. ^[3]

Function

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Suppressor of cytokine signaling 4". Retrieved 2016-02-23.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.