SP110

SP110
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1UFN
Identifiers
Aliases	SP110, IFI41, IFI75, IPR1, VODI, SP110 nuclear body protein
External IDs	MGI: 3783243 HomoloGene: 82192 GeneCards: SP110
Genetically Related Diseases
obesity[1]
Gene ontology Molecular function • signal transducer activity • zinc ion binding • metal ion binding • DNA binding Cellular component • nucleolus • nucleus Biological process • regulation of transcription, DNA-templated • transcription, DNA-templated • viral process • signal transduction Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3431	101056250
Ensembl	n/a	ENSMUSG00000079222
UniProt	Q9HB58	n/a
RefSeq (mRNA)	NM_001185015 NM_004509 NM_004510 NM_080424	XM_011238724
RefSeq (protein)	NP_001171944.1 NP_004500.3 NP_536349.2	n/a
Location (UCSC)	Chr 2: 230.18 – 230.22 Mb	n/a
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.^[4][5][6]

The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified.^[6]

References

1. "Diseases that are genetically associated with SP110 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. Kadereit S, Gewert DR, Galabru J, Hovanessian AG, Meurs EF (Dec 1993). "Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins". J Biol Chem. 268 (32): 24432–41. PMID 7693701.
5. Welsh GI, Kadereit S, Coccia EM, Hovanessian AG, Meurs EF (Aug 1999). "Colocalization within the nucleolus of two highly related IFN-induced human nuclear phosphoproteins with nucleolin". Exp Cell Res. 250 (1): 62–74. doi:10.1006/excr.1999.4505. PMID 10388521.
6. "Entrez Gene: SP110 SP110 nuclear body protein".

External links

• GeneReviews/NCBI/NIH/UW entry on Hepatic Veno-Occlusive Disease with Immunodeficiency

Further reading

• Bloch DB, Nakajima A, Gulick T, et al. (2000). "Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.". Mol. Cell. Biol. 20 (16): 6138–46. doi:10.1128/MCB.20.16.6138-6146.2000. PMC 86089. PMID 10913195.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages.". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042.
• Watashi K, Hijikata M, Tagawa A, et al. (2003). "Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.". Mol. Cell. Biol. 23 (21): 7498–509. doi:10.1128/MCB.23.21.7498-7509.2003. PMC 207568. PMID 14559998.
• Nicewonger J, Suck G, Bloch D, Swaminathan S (2004). "Epstein-Barr virus (EBV) SM protein induces and recruits cellular Sp110b to stabilize mRNAs and enhance EBV lytic gene expression.". J. Virol. 78 (17): 9412–22. doi:10.1128/JVI.78.17.9412-9422.2004. PMC 506926. PMID 15308735.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Roscioli T, Cliffe ST, Bloch DB, et al. (2006). "Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.". Nat. Genet. 38 (6): 620–2. doi:10.1038/ng1780. PMID 16648851.
• Tosh K, Campbell SJ, Fielding K, et al. (2006). "Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.". Proc. Natl. Acad. Sci. U.S.A. 103 (27): 10364–8. doi:10.1073/pnas.0603340103. PMC 1502463. PMID 16803959.
• Thye T, Browne EN, Chinbuah MA, et al. (2006). "No associations of human pulmonary tuberculosis with Sp110 variants.". J. Med. Genet. 43 (7): e32. doi:10.1136/jmg.2005.037960. PMC 2564561. PMID 16816019.
• Warren EH, Vigneron NJ, Gavin MA, et al. (2006). "An antigen produced by splicing of noncontiguous peptides in the reverse order.". Science. 313 (5792): 1444–7. doi:10.1126/science.1130660. PMID 16960008.
• Szeszko JS, Healy B, Stevens H, et al. (2007). "Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis.". Hum. Genet. 121 (2): 155–60. doi:10.1007/s00439-006-0293-z. PMID 17149599.
• Babb C, Keet EH, van Helden PD, Hoal EG (2007). "SP110 polymorphisms are not associated with pulmonary tuberculosis in a South African population.". Hum. Genet. 121 (3-4): 521–2. doi:10.1007/s00439-007-0335-1. PMID 17287948.
• Cliffe ST, Wong M, Taylor PJ, et al. (2007). "The first prenatal diagnosis for veno-occlusive disease and immunodeficiency syndrome, an autosomal recessive condition associated with mutations in SP110.". Prenat. Diagn. 27 (7): 674–6. doi:10.1002/pd.1759. PMID 17510920.
• de la Fuente J, Manzano-Roman R, Blouin EF, et al. (2007). "Sp110 transcription is induced and required by Anaplasma phagocytophilum for infection of human promyelocytic cells.". BMC Infect. Dis. 7: 110. doi:10.1186/1471-2334-7-110. PMC 2039740. PMID 17883869.