Spondin 2

SPON2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3D34
Identifiers
Aliases	SPON2, DIL-1, DIL1, M-SPONDIN, MINDIN, spondin 2
External IDs	MGI: 1923724 HomoloGene: 40843 GeneCards: SPON2
Gene ontology Molecular function • antigen binding • lipopolysaccharide binding • metal ion binding • protein binding Cellular component • proteinaceous extracellular matrix • extracellular fluid • extracellular region • extracellular exosome Biological process • mast cell mediated immunity • positive regulation of macrophage cytokine production • immune system process • defense response to fungus • axon guidance • response to lipopolysaccharide • cell adhesion • defense response to virus • defense response to bacterium • positive regulation of interleukin-6 production • positive regulation of tumor necrosis factor production • innate immune response • cellular response to lipopolysaccharide • opsonization • induction of bacterial agglutination Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10417	100689
Ensembl	ENSG00000159674	ENSMUSG00000037379
UniProt	Q9BUD6	Q8BMS2
RefSeq (mRNA)	NM_012445 NM_001128325 NM_001199021	NM_133903
RefSeq (protein)	NP_001121797.1 NP_001185950.1 NP_036577.1	NP_598664.3
Location (UCSC)	Chr 4: 1.17 – 1.21 Mb	Chr 5: 33.2 – 33.22 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Spondin 2, also known as mindin, is a protein that in humans is encoded by the SPON2 gene. ^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. "Entrez Gene: Spondin 2, extracellular matrix protein". Retrieved 2015-09-03.

Further reading

• Yan, L; Wei, X; Tang, Q. Z.; Feng, J; Zhang, Y; Liu, C; Bian, Z. Y.; Zhang, L. F.; Chen, M; Bai, X; Wang, A. B.; Fassett, J; Chen, Y; He, Y. W.; Yang, Q; Liu, P. P.; Li, H (2011). "Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling". Cardiovascular Research. 92 (1): 85–94. doi:10.1093/cvr/cvr159. PMC 3657538. PMID 21632881.
• Qian, X; Li, C; Pang, B; Xue, M; Wang, J; Zhou, J (2012). "Spondin-2 (SPON2), a more prostate-cancer-specific diagnostic biomarker". PLoS ONE. 7 (5): e37225. doi:10.1371/journal.pone.0037225. PMC 3352876. PMID 22615945.
• Feinstein, Y; Klar, A (2004). "The neuronal class 2 TSR proteins F-spondin and Mindin: A small family with divergent biological activities". The International Journal of Biochemistry & Cell Biology. 36 (6): 975–80. doi:10.1016/j.biocel.2004.01.002. PMID 15094111.
• Li, Y; Cao, C; Jia, W; Yu, L; Mo, M; Wang, Q; Huang, Y; Lim, J. M.; Ishihara, M; Wells, L; Azadi, P; Robinson, H; He, Y. W.; Zhang, L; Mariuzza, R. A. (2009). "Structure of the F-spondin domain of mindin, an integrin ligand and pattern recognition molecule". The EMBO Journal. 28 (3): 286–97. doi:10.1038/emboj.2008.288. PMC 2637340. PMID 19153605.
• Liao, C. H.; Yeh, S. C.; Huang, Y. H.; Chen, R. N.; Tsai, M. M.; Chen, W. J.; Chi, H. C.; Tai, P. J.; Liao, C. J.; Wu, S. M.; Cheng, W. L.; Pai, L. M.; Lin, K. H. (2010). "Positive regulation of spondin 2 by thyroid hormone is associated with cell migration and invasion". Endocrine Related Cancer. 17 (1): 99–111. doi:10.1677/ERC-09-0050. PMID 19903741.
• Murakoshi, M; Tanimoto, M; Gohda, T; Hagiwara, S; Takagi, M; Horikoshi, S; Tomino, Y (2011). "Mindin: A novel marker for podocyte injury in diabetic nephropathy". Nephrology Dialysis Transplantation. 26 (7): 2153–60. doi:10.1093/ndt/gfq708. PMID 21098016.
• Manda, R; Kohno, T; Matsuno, Y; Takenoshita, S; Kuwano, H; Yokota, J (1999). "Identification of genes (SPON2 and C20orf2) differentially expressed between cancerous and noncancerous lung cells by mRNA differential display". Genomics. 61 (1): 5–14. doi:10.1006/geno.1999.5939. PMID 10512675.
• Choy, K. W.; Wang, C. C.; Ogura, A; Lau, T. K.; Rogers, M. S.; Ikeo, K; Gojobori, T; Lam, D. S.; Pang, C. P. (2006). "Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes". Physiological Genomics. 25 (1): 9–15. doi:10.1152/physiolgenomics.00121.2005. PMID 16368877.
• Kong, A; Thorleifsson, G; Stefansson, H; Masson, G; Helgason, A; Gudbjartsson, D. F.; Jonsdottir, G. M.; Gudjonsson, S. A.; Sverrisson, S; Thorlacius, T; Jonasdottir, A; Hardarson, G. A.; Palsson, S. T.; Frigge, M. L.; Gulcher, J. R.; Thorsteinsdottir, U; Stefansson, K (2008). "Sequence variants in the RNF212 gene associate with genome-wide recombination rate". Science. 319 (5868): 1398–401. doi:10.1126/science.1152422. PMID 18239089.