SPRED3
| SPRED3 | ||||||
|---|---|---|---|---|---|---|
| Identifiers | ||||||
| Aliases | SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3 | |||||
| External IDs | MGI: 2142186 HomoloGene: 28061 GeneCards: SPRED3 | |||||
| Orthologs | ||||||
| Species | Human | Mouse | ||||
| Entrez | ||||||
| Ensembl | ||||||
| UniProt | ||||||
| RefSeq (mRNA) | ||||||
| RefSeq (protein) | ||||||
| Location (UCSC) | Chr 19: 38.39 – 38.4 Mb | Chr 7: 29.16 – 29.17 Mb | ||||
| PubMed search | [1] | [2] | ||||
| Wikidata | ||||||
| View/Edit Human | View/Edit Mouse |
Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.[3]
Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.[3][4]
References
- ↑ "Human PubMed Reference:".
- ↑ "Mouse PubMed Reference:".
- 1 2 "Entrez Gene: sprouty-related".
- ↑ Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. doi:10.1074/jbc.M405189200. PMID 15465815.
Further reading
- Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. doi:10.1016/S0006-291X(03)00259-6. PMID 12646235.
- Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. doi:10.1007/s10048-003-0164-x. PMID 14618415.
- King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. doi:10.1016/j.jhep.2005.10.031. PMID 16478641.
- Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. doi:10.1016/j.bbrc.2006.10.150. PMID 17094949.
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