STEAP3

STEAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VNS, 2VQ3
Identifiers
Aliases	STEAP3, AHMIO2, STMP3, TSAP6, dudlin-2, dudulin-2, pHyde, STEAP3 metalloreductase
External IDs	MGI: 1915678 HomoloGene: 10084 GeneCards: STEAP3
Gene ontology Molecular function • oxidoreductase activity • protein binding • ferric-chelate reductase (NADPH) activity • metal ion binding • cupric reductase activity • oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor Cellular component • integral component of membrane • multivesicular body • endosome • endosome membrane • membrane • integral component of plasma membrane • cytoplasm Biological process • apoptotic process • protein secretion • cell cycle • iron ion homeostasis • copper ion import • ion transport • oxidation-reduction process • transferrin transport • transport • ferric iron import into cell • regulation of apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55240	68428
Ensembl	ENSG00000115107	ENSMUSG00000026389
UniProt	Q658P3	Q8CI59
RefSeq (mRNA)	NM_001008410 NM_018234 NM_138637 NM_182915	NM_001085409 NM_133186
RefSeq (protein)	NP_001008410.1 NP_060704.2 NP_619543.2 NP_878919.2	NP_001078878.1 NP_573449.2
Location (UCSC)	Chr 2: 119.22 – 119.27 Mb	Chr 1: 120.19 – 120.27 Mb
PubMed search	[1]	[2]
Wikidata

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View/Edit Mouse

Metalloreductase STEAP3 is an enzyme that in humans is encoded by the STEAP3 gene.^[3][4]

STEAP3 is a metalloreductase, capable of coverting iron from an insoluble ferric (Fe³⁺) to a soluble ferrous (Fe²⁺) form.^[5]

Interactions

STEAP3 has been shown to interact with BNIP3L^[3] and PKMYT1.^[3]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc Natl Acad Sci U S A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.
4. "Entrez Gene: STEAP3 STEAP family member 3".
5. Ohgami RS, Campagna DR, McDonald A, Fleming MD (August 2006). "The Steap proteins are metalloreductases". Blood. 108 (4): 1388–94. doi:10.1182/blood-2006-02-003681. PMC 1785011. PMID 16609065.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Korkmaz KS, Elbi C, Korkmaz CG, Loda M, Hager GL, Saatcioglu F (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.". J. Biol. Chem. 277 (39): 36689–96. doi:10.1074/jbc.M202414200. PMID 12095985.
• Amzallag N, Passer BJ, Allanic D, Segura E, Théry C, Goud B, Amson R, Telerman A (2004). "TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway.". J. Biol. Chem. 279 (44): 46104–12. doi:10.1074/jbc.M404850200. PMID 15319436.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.