STRN

STRN
Identifiers
Aliases	STRN, SG2NA, PPP2R6A, striatin
External IDs	MGI: 1333757 HomoloGene: 2380 GeneCards: STRN
Gene ontology Molecular function • protein phosphatase 2A binding • protein complex binding • estrogen receptor binding • protein binding • calmodulin binding • armadillo repeat domain binding Cellular component • cytoplasm • neuronal cell body • postsynaptic membrane • dendritic spine • protein phosphatase type 2A complex • cell projection • membrane • postsynaptic density • bicellular tight junction Biological process • dendrite development • Wnt signaling pathway • locomotory behavior • negative regulation of cell proliferation • bicellular tight junction assembly Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6801	268980
Ensembl	ENSG00000115808	ENSMUSG00000024077
UniProt	O43815	O55106
RefSeq (mRNA)	NM_003162	NM_011500
RefSeq (protein)	NP_003153.2	NP_035630.2
Location (UCSC)	Chr 2: 36.84 – 36.97 Mb	Chr 17: 78.65 – 78.74 Mb
PubMed search	[1]	[2]
Wikidata

View/Edit Human

View/Edit Mouse

Striatin is a protein that in humans is encoded by the STRN gene.^[3][4][5]

Interactions

STRN has been shown to interact with:

• CTTNBP2NL,^[6]
• CTTNBP2,^[6]
• FAM40A,^[6]
• MOBKL3,^[6]
• PDCD10,^[6]
• PPP2CA,^[6]
• PPP2R1A,^[6]
• RP6-213H19.1,^[6]
• STK24,^[6][7]
• STK25,^[6]
• STRN3,^[6] and
• TRAF3IP3.^[6]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Moqrich A, Mattei MG, Bartoli M, Rakitina T, Baillat G, Monneron A, Castets F (Jul 1998). "Cloning of human striatin cDNA (STRN), gene mapping to 2p22-p21, and preferential expression in brain". Genomics. 51 (1): 136–9. doi:10.1006/geno.1998.5342. PMID 9693043.
4. Castets F, Bartoli M, Barnier JV, Baillat G, Salin P, Moqrich A, Bourgeois JP, Denizot F, Rougon G, Calothy G, Monneron A (Aug 1996). "A novel calmodulin-binding protein, belonging to the WD-repeat family, is localized in dendrites of a subset of CNS neurons". The Journal of Cell Biology. 134 (4): 1051–62. doi:10.1083/jcb.134.4.1051. PMC 2120968. PMID 8769426.
5. "Entrez Gene: STRN striatin, calmodulin binding protein".
6. Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, Chaudhry S, Chen GI, Sicheri F, Nesvizhskii AI, Aebersold R, Raught B, Gingras AC (Jan 2009). "A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein". Molecular & Cellular Proteomics. 8 (1): 157–71. doi:10.1074/mcp.M800266-MCP200. PMC 2621004. PMID 18782753.
7. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Moreno CS, Park S, Nelson K, Ashby D, Hubalek F, Lane WS, Pallas DC (Feb 2000). "WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A". The Journal of Biological Chemistry. 275 (8): 5257–63. doi:10.1074/jbc.275.8.5257. PMC 3505218. PMID 10681496.
• Gaillard S, Bartoli M, Castets F, Monneron A (Nov 2001). "Striatin, a calmodulin-dependent scaffolding protein, directly binds caveolin-1". FEBS Letters. 508 (1): 49–52. doi:10.1016/S0014-5793(01)03020-4. PMID 11707266.
• Huang Y, Tang R, Dai J, Gu S, Zhao W, Cheng C, Xu M, Zhou Z, Ying K, Xi Y, Mao Y (2002). "A novel human hydroxysteroid dehydrogenase like 1 gene (HSDL1) is highly expressed in reproductive tissues". Molecular Biology Reports. 28 (4): 185–91. doi:10.1023/A:1015726217890. PMID 12153137.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
• Lu Q, Pallas DC, Surks HK, Baur WE, Mendelsohn ME, Karas RH (Dec 2004). "Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha". Proceedings of the National Academy of Sciences of the United States of America. 101 (49): 17126–31. doi:10.1073/pnas.0407492101. PMC 534607. PMID 15569929.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.