STX17

STX17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WY4,%%s4WY4
Identifiers
Aliases	STX17
External IDs	MGI: 1914977 HomoloGene: 9917 GeneCards: STX17
Genetically Related Diseases
alopecia areata[1]
Gene ontology Molecular function • SNAP receptor activity • protein binding • protein phosphatase binding • protein kinase binding • SNARE binding Cellular component • HOPS complex • cytoplasm • integral component of membrane • cytosol • ER-mitochondrion membrane contact site • rough endoplasmic reticulum • endoplasmic reticulum membrane • membrane • lysosomal membrane • autophagosome membrane • SNARE complex • smooth endoplasmic reticulum membrane • endoplasmic reticulum • mitochondrion • ER to Golgi transport vesicle membrane • ER to Golgi transport vesicle • endoplasmic reticulum-Golgi intermediate compartment membrane • cytoplasmic vesicle • endoplasmic reticulum-Golgi intermediate compartment Biological process • endoplasmic reticulum-Golgi intermediate compartment organization • Golgi organization • protein localization to pre-autophagosomal structure • autophagy • ER to Golgi vesicle-mediated transport • vesicle docking • autophagosome maturation • transport • intracellular protein transport • vesicle fusion • vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	55014	67727
Ensembl	ENSG00000136874	ENSMUSG00000061455
UniProt	P56962	Q9D0I4
RefSeq (mRNA)	NM_017919	NM_026343
RefSeq (protein)	NP_060389.2	NP_080619.2
Location (UCSC)	Chr 9: 99.91 – 99.97 Mb	Chr 4: 48.12 – 48.19 Mb
PubMed search	[2]	[3]
Wikidata

View/Edit Human

View/Edit Mouse

Syntaxin 17 is a protein that in humans is encoded by the STX17 gene.^[4]

References

1. "Diseases that are genetically associated with STX17 view/edit references on wikidata".
2. "Human PubMed Reference:".
3. "Mouse PubMed Reference:".
4. "Entrez Gene: Syntaxin 17".

Further reading

• Itakura E, Kishi-Itakura C, Mizushima N (2012). "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes". Cell. 151 (6): 1256–69. doi:10.1016/j.cell.2012.11.001. PMID 23217709.
• Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM (2010). "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity". Nature. 466 (7302): 113–7. doi:10.1038/nature09114. PMC 2921172. PMID 20596022.
• Muppirala M, Gupta V, Swarup G (2011). "Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi". Biol. Cell. 103 (7): 333–50. doi:10.1042/BC20110006. PMID 21545355.
• Zhao ZZ, Duffy DL, Thomas SA, Martin NG, Hayward NK, Montgomery GW (2009). "Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma". Melanoma Res. 19 (2): 80–6. doi:10.1097/CMR.0b013e328322fc45. PMC 3665505. PMID 19209086.
• Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
• Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/s0092-8674(00)80191-9. PMID 9094723.
• Steegmaier M, Oorschot V, Klumperman J, Scheller RH (2000). "Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics". Mol. Biol. Cell. 11 (8): 2719–31. doi:10.1091/mbc.11.8.2719. PMC 14951. PMID 10930465.