SULT1B1

SULT1B1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z5F, 3CKL
Identifiers
Aliases	SULT1B1, ST1B1, ST1B2, SULT1B2, sulfotransferase family 1B member 1
External IDs	MGI: 2136282 HomoloGene: 69169 GeneCards: SULT1B1
Gene ontology Molecular function • transferase activity • sulfotransferase activity • protein binding • aryl sulfotransferase activity Cellular component • cytoplasm • cytosol Biological process • steroid metabolic process • phenol-containing compound metabolic process • epithelial cell differentiation • 3'-phosphoadenosine 5'-phosphosulfate metabolic process • sulfation • lipid metabolic process • cellular biogenic amine metabolic process • flavonoid metabolic process • thyroid hormone metabolic process • xenobiotic metabolic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	27284	56362
Ensembl	ENSG00000173597	ENSMUSG00000029269
UniProt	O43704	Q9QWG7
RefSeq (mRNA)	NM_014465	NM_019878
RefSeq (protein)	NP_055280.2	NP_063931.1
Location (UCSC)	Chr 4: 69.72 – 69.79 Mb	Chr 5: 87.51 – 87.54 Mb
PubMed search	[1]	[2]
Wikidata

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Sulfotransferase family cytosolic 1B member 1 is an enzyme that in humans is encoded by the SULT1B1 gene.^[3][4][5]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. However, the total genomic length of this gene is greater than that of other SULT1 genes.^[5]

References

1. "Human PubMed Reference:".
2. "Mouse PubMed Reference:".
3. Meinl W, Glatt H (Nov 2001). "Structure and localization of the human SULT1B1 gene: neighborhood to SULT1E1 and a SULT1D pseudogene". Biochem Biophys Res Commun. 288 (4): 855–62. doi:10.1006/bbrc.2001.5829. PMID 11688987.
4. Fujita K, Nagata K, Ozawa S, Sasano H, Yamazoe Y (Feb 1998). "Molecular cloning and characterization of rat ST1B1 and human ST1B2 cDNAs, encoding thyroid hormone sulfotransferases". J Biochem. 122 (5): 1052–61. doi:10.1093/oxfordjournals.jbchem.a021846. PMID 9443824.
5. "Entrez Gene: SULT1B1 sulfotransferase family, cytosolic, 1B, member 1".

Further reading

• Weinshilboum RM, Otterness DM, Aksoy IA, et al. (1997). "Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes.". FASEB J. 11 (1): 3–14. PMID 9034160.
• Glatt H, Engelke CE, Pabel U, et al. (2000). "Sulfotransferases: genetics and role in toxicology.". Toxicol. Lett. 112-113 (1-3): 341–8. doi:10.1016/S0378-4274(99)00214-3. PMID 10720750.
• Glatt H (2001). "Sulfotransferases in the bioactivation of xenobiotics.". Chem. Biol. Interact. 129 (1-2): 141–70. doi:10.1016/S0009-2797(00)00202-7. PMID 11154739.
• Glatt H, Boeing H, Engelke CE, et al. (2001). "Human cytosolic sulphotransferases: genetics, characteristics, toxicological aspects.". Mutat. Res. 482 (1-2): 27–40. doi:10.1016/S0027-5107(01)00207-X. PMID 11535246.
• Wang J, Falany JL, Falany CN (1998). "Expression and characterization of a novel thyroid hormone-sulfating form of cytosolic sulfotransferase from human liver.". Mol. Pharmacol. 53 (2): 274–82. PMID 9463486.
• Tsoi C, Falany CN, Morgenstern R, Swedmark S (2001). "Molecular cloning, expression, and characterization of a canine sulfotransferase that is a human ST1B2 ortholog.". Arch. Biochem. Biophys. 390 (1): 87–92. doi:10.1006/abbi.2001.2373. PMID 11368519.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Dombrovski L, Dong A, Bochkarev A, Plotnikov AN (2006). "Crystal structures of human sulfotransferases SULT1B1 and SULT1C1 complexed with the cofactor product adenosine-3'- 5'-diphosphate (PAP).". Proteins. 64 (4): 1091–4. doi:10.1002/prot.21048. PMID 16804942.
• Allali-Hassani A, Pan PW, Dombrovski L, et al. (2007). "Structural and chemical profiling of the human cytosolic sulfotransferases.". PLoS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840. PMID 17425406.