Cefalotin
Clinical data | |
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AHFS/Drugs.com | International Drug Names |
MedlinePlus | a682860 |
Pregnancy category | |
Routes of administration | Intravenous |
ATC code | J01DB03 (WHO) |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | n/a |
Protein binding | 65 to 80% |
Metabolism | Hepatic |
Biological half-life | 30 minutes to 1 hour |
Excretion | Renal |
Identifiers | |
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CAS Number | 153-61-7 |
PubChem (CID) | 6024 |
DrugBank | DB00456 |
ChemSpider | 5802 |
UNII | R72LW146E6 |
KEGG | D07635 |
ChEBI | CHEBI:124991 |
ChEMBL | CHEMBL617 |
ECHA InfoCard | 100.005.288 |
Chemical and physical data | |
Formula | C16H16N2O6S2 |
Molar mass | 396.44 g/mol |
3D model (Jmol) | Interactive image |
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Cefalotin (INN) /ˌsɛfəˈloʊtᵻn/ or cephalothin (USAN) /ˌsɛfəˈloʊθᵻn/ is a first-generation cephalosporin antibiotic.[1] It was the first cephalosporin marketed (1964) and continues to be widely used.[2] It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is marketed as Keflin (Lilly) and under other trade names.[3]
References
- ↑ Hameed, T. K.; Robinson, J. L. (2002). "Review of the use of cephalosporins in children with anaphylactic reactions from penicillins". The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses. 13 (4): 253–8. PMC 2094874. PMID 18159398.
- ↑ David Greenwood (21 February 2008). Antimicrobial Drugs: Chronicle of a Twentieth Century Medical Triumph. OUP Oxford. pp. 128–. ISBN 978-0-19-953484-5.
- ↑ International Drug Names: Cefalotin
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