Semuloparin sodium

Semuloparin sodium
Clinical data
ATC code	None
Legal status
Legal status	Investigational
Identifiers
Synonyms	AVE-5026
CAS Number	9041-08-1
ChemSpider	none
UNII	V5T10N50RD^Y
ECHA InfoCard	100.110.590
Chemical and physical data
Molar mass	2000–3000 g/mol (average)

Semuloparin (INN, USAN) is an experimental antithrombotic being developed by Sanofi-Aventis and belongs to the group of low molecular weight heparins (LMWH).^[1] It has completed Phase III clinical trials for the prevention of thromboembolism following various kinds of surgery such as hip replacement,^[2] as well as for patients undergoing chemotherapy.^[3]

Like bemiparin, semuloparin is classified as an ultra-LMWH because of its low molecular mass of 2000–3000 g/mol on average. (Enoxaparin has 4500 g/mol) These heparins have lower anti-thrombin activity than classical LMWHs and act mainly on factor Xa, reducing the risk of bleeding.^[4]^[5]

References

↑ Gomez-Outes, A.; Suarez-Gea, M. L.; Lecumberri, R.; Rocha, E.; Pozo-Hernandez, C.; Vargas-Castrillon, E. (2010). "New parenteral anticoagulants in development". Therapeutic Advances in Cardiovascular Disease. 5 (1): 33–59. doi:10.1177/1753944710387808. PMID 21045018.
↑ Clinical trial number NCT00697099 for "Evaluation of AVE5026 as Compared to Enoxaparin for the Prevention of Thromboembolism in Patients Undergoing Total Hip Replacement Surgery (SAVE-HIP1)" at ClinicalTrials.gov
↑ Clinical trial number NCT00694382 for "Evaluation of AVE5026 in the Prevention of Venous Thromboembolism in Cancer Patients Undergoing Chemotherapy (SAVE-ONCO)" at ClinicalTrials.gov
↑ Jeske, W. P.; Hoppensteadt, D.; Gray, A.; Walenga, J. M.; Cunanan, J.; Myers, L.; Fareed, J.; Bayol, A.; Rigal, H. L. N.; Viskov, C. (2011). "A common standard is inappropriate for determining the potency of ultra low molecular weight heparins such as semuloparin and bemiparin". Thrombosis Research. 128 (4): 361–367. doi:10.1016/j.thromres.2011.03.001. PMID 21458847.
↑ Statement On A Nonproprietary Name Adopted By The Usan Council: Semuloparin Sodium

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban^§ Tirofiban

ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor

Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal

Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban^§

Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal

Other	Cloricromen Ditazole Vorapaxar

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	Low molecular weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin^‡ Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide

Direct Xa inhibitors ("xabans")	Apixaban Betrixaban^† Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban

Direct thrombin (IIa) inhibitors

Other

Thrombolytic drugs/
fibrinolytics

Non-medicinal

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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