Senicapoc

Senicapoc

Names
IUPAC name 2,2-bis(4-fluorophenyl)-2-phenylacetamide
Identifiers
CAS Number	289656-45-7
3D model (Jmol)	Interactive image
ChemSpider	187516
IUPHAR/BPS	2331
KEGG	D06640
PubChem	216327
UNII	TS6G201A6Q
InChI InChI=1S/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) Key: SCTZUZTYRMOMKT-UHFFFAOYSA-N InChI=1/C20H15F2NO/c21-17-10-6-15(7-11-17)20(19(23)24,14-4-2-1-3-5-14)16-8-12-18(22)13-9-16/h1-13H,(H2,23,24) Key: SCTZUZTYRMOMKT-UHFFFAOYAR
SMILES C1=CC=C(C=C1)C(C2=CC=C(C=C2)F)(C3=CC=C(C=C3)F)C(=O)N
Properties
Chemical formula	C20H15F2NO
Molar mass	323.34 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Senicapoc (ICA-17043) is a Gardos channel blocker.^[1][2]

It has been proposed for use in sickle cell anemia.^[3]

The Gardos channel has been identified as KCNN4.^[4]

The "ICA" is for Icagen, which is developing the drug.^[5]

References

1. Ataga KI, Smith WR, De Castro LM, et al. (April 2008). "Efficacy and safety of the Gardos channel blocker, senicapoc (ICA-17043), in patients with sickle cell anemia". Blood. 111 (8): 3991–7. doi:10.1182/blood-2007-08-110098. PMID 18192510.
2. McNaughton-Smith GA, Burns JF, Stocker JW, et al. (February 2008). "Novel inhibitors of the Gardos channel for the treatment of sickle cell disease". J. Med. Chem. 51 (4): 976–82. doi:10.1021/jm070663s. PMID 18232633.
3. Ataga KI; Stocker J (February 2009). "Senicapoc (ICA-17043): a potential therapy for the prevention and treatment of hemolysis-associated complications in sickle cell anemia". Expert Opin Investig Drugs. 18 (2): 231–9. doi:10.1517/13543780802708011. PMID 19236269.
4. Hoffman JF; Joiner W; Nehrke K; Potapova O; Foye K; Wickrema A (June 2003). "The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells". Proc. Natl. Acad. Sci. U.S.A. 100 (12): 7366–71. doi:10.1073/pnas.1232342100. PMC 165881. PMID 12773623.
5. "Icagen - Press Release". Retrieved 2008-12-22.