SESN2

SESN2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases SESN2, HI95, SES2, SEST2, sestrin 2
External IDs MGI: 2651874 HomoloGene: 12873 GeneCards: SESN2
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

83667

230784

Ensembl

ENSG00000130766

ENSMUSG00000028893

UniProt

P58004

P58043

RefSeq (mRNA)

NM_031459

NM_144907

RefSeq (protein)

NP_113647.1

NP_659156.1

Location (UCSC) Chr 1: 28.26 – 28.28 Mb Chr 4: 132.49 – 132.51 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

Sestrin-2 also known as Hi95 is a protein that in humans is encoded by the SESN2 gene.[3][4][5]

Function

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.[5][6] The Sestrins constitute a family of evolutionarily-conserved stress-inducible proteins that suppress oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)- mammalian target of rapamycin (mTOR) signaling. By virtue of these activities, the Sestrins serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative damage, fat accumulation, mitochondrial dysfunction and muscle degeneration that resemble accelerated tissue aging.[5][7]

See also

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Peeters H, Debeer P, Bairoch A, Wilquet V, Huysmans C, Parthoens E, Fryns JP, Gewillig M, Nakamura Y, Niikawa N, Van de Ven W, Devriendt K (Apr 2003). "PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse". Hum Genet. 112 (5–6): 573–80. doi:10.1007/s00439-003-0917-5. PMID 12607115.
  4. Budanov AV, Shoshani T, Faerman A, Zelin E, Kamer I, Kalinski H, Gorodin S, Fishman A, Chajut A, Einat P, Skaliter R, Gudkov AV, Chumakov PM, Feinstein E (Aug 2002). "Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability". Oncogene. 21 (39): 6017–31. doi:10.1038/sj.onc.1205877. PMID 12203114.
  5. 1 2 3 "Entrez Gene: SESN2 sestrin 2".
  6. Lee JH, Bodmer R, Bier E, Karin M (June 2010). "Sestrins at the crossroad between stress and aging". Aging (Albany NY). 2 (6): 369–74. doi:10.18632/aging.100157. PMC 2919257Freely accessible. PMID 20606249.
  7. Lee JH, Budanov AV, Karin M (Dec 2013). "Sestrins orchestrate cellular metabolism to attenuate aging". Cell Metab. 18 (6): 792–801. doi:10.1016/j.cmet.2013.08.018. PMC 3858445Freely accessible. PMID 24055102.

Further reading


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