Shimon Sakaguchi

Shimon Sakaguchi 坂口 志文
at the Royal Ontario Museum on October 29, 2015
Born	January 19, 1951 Shiga Prefecture, Japan
Nationality	Japanese
Fields	pathology, immunology
Institutions	Johns Hopkins University Stanford University Scripps Research Institute RIKEN University of Tokyo University of Osaka
Education	University of Kyoto
Known for	Regulatory T cells

Shimon Sakaguchi (坂口 志文 Sakaguchi Shimon, born January 19, 1951 in Shiga) is an immunologist and a Distinguished Professor of Osaka University. He is best known for the discovery of regulatory T cells and to describe their role in the immune system. This discovery is used in the treatment of cancer and autoimmune diseases.

Biography

Sakaguchi studied at the University of Kyoto; he obtained a Master's degree in 1976 and then a Ph.D in 1982. In Kyoto, he continued his study of pathology and immunology. As postdoc, he worked at the Johns Hopkins University and to Stanford University in the United States. In 1989, he began his teaching career and became an assistant professor at the Scripps Research Institute, and then returned to Japan in 1991, where he became a researcher at the RIKEN and director of the Department of Pathology immune Metropolitan Institute Tokyo. In 1999 he became professor of experimental pathology at Kyoto University. Since 2007 he is a teacher in his own laboratory at the Osaka University.

In 2015, the news agency Thomson Reuters signals Shimon Sakaguchi among potential recipients of the Nobel Prize in Physiology or Medicine.^[1]

Awards and Recognition

• 2004: William B. Coley Award;^[2]
• 2008: Keio Medical Science Prize;^[3]
• 2009: Medals of Honor (Japan), purple ribbon^[4]
• 2011: Asahi Prize;^[5]
• 2012: Foreign member of the National Academy of Sciences;^[6]
• 2015: Gairdner Foundation International Award.^[7]

Publications

with John Dirks, Kenjirō Monji and D. Lorne Tyrrell (at the Royal Ontario Museum on October 29, 2015)

• Sakaguchi, N., Takahashi, T., Hata, H., Nomura, T. Tagami, T. Yamazaki, S., Sakihama, T., Matsutani, T., Negishi, I. , Nakatsuru, S., and Sakaguchi, S., "Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice", Nature , No. 426, pp. 454–60, 2003.
• Sakaguchi, S., "Naturally Arising Regulatory CD4 + T cells for immunologic self-tolelance and negative control of immune responses", Annual Review of Immunology '.
• Hori, S. Nomura, T., and Sakaguchi, S., "Control of Regulatory T cell development by the transcription factor Foxp3," Science , No. 299 pp. 1057–1061, 2003.
• Wood, and K. Sakaguchi, S., "Regulatory T cells in transplantation," Nature Review of Immunology No. 3, pp. 199–210, 2003.
• Shimizu, J. Yamazaki, S. Takahashi, T., Ishida, Y., and Sakaguchi, S., "Stimulation of CD4 + CD25 + Regulatory T cells through GITR breaks immunological self-tolerance 'Nature Immunology' ' No. 3, pp. 135-142, 2002.
• Sakaguchi, S. Sakaguchi, N. Shimizu, J. Yamazaki, S., Sakihama. T. Itoh, M., Kuniyasu, Y., Nomura, T., Toda and Mr. Takahashi, T., "Immunologic tolerance maintained by CD25 + CD4 + Regulatory T cells: Their role in controlling autoimmunity common, tumor immunity, and transplantation tolerance ',' Immunology Review , No. 182, pp. 18-32, 2001.
• Sakaguchi, S., "Regulatory T cells: key controllers of immunologic self-tolerance ',' ', No. 101, pp' Cell. '. 455-458, 2000.
• Takahashi, T. Tagami, T. Yamazaki, S., WEDEN, T., Shimizu, J., Sakaguchi, N., Mak, TW and Sakaguchi, S., "Dominating immunologic self- tolerance maintained by CD25 + CD4 + Regulatory T cells constitutively Expressing CTLA-4. J 'Exp. Med., No. 192, pp. 303-309, 2000.
• Itoh, M., Takahashi, T., Sakaguchi, N., Kuniyasu, Y. Shimizu, J., Ohtsuka, F. and Sakaguchi, S., "Thymus and autoimmunity. Production of CD25 + CD4 + naturally anergic and suppressive T cells have a key function of the thymus in Maintaining immunologic self-tolerance ',' 'Journal of Immunology' ' No. 162, pp. 5317-5326, 1999.
• Asano, M., Toda, M., Sakaguchi, N. and Sakaguchi, S., "Autoimmune disease as a consequence of developmental abnormality of a T-cell subpopulation," J. Exp. Med., No 184 p.  387-396 1996.

References

1. Announcing the 2015 Citation Laureates by Thomson Reuters.
2. William B. Coley Award-Award, Cancer Research Institute '(cancerresearch.org)
3. The 2008 Keio Medical Science Prize Awardees, Keiō University
4. "Distinguished Professor Shimon SAKAGUCHI of IFReC awarded Canada Gairdner International Award". Osaka University. March 26, 2015.
5. The Asahi Prize Asahi Shimbun
6. Shimon Sakaguchi National Academy of Sciences
7. Shimon Sakaguchi MD, PhD, Gairdner Foundation

External links

• Osaka University Immunology Frontier Research Center.