Spi-1 (PU.1) 5' UTR regulatory element

Spi-1 (PU.1) 5' UTR regulatory element

Identifiers
Symbol Spi-1
Rfam RF00232
Other data
RNA type Cis-reg
Domain(s) Eukaryota
SO 0000204

The Spi-1 (PU.1) 5' UTR regulatory element is an RNA element found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold.[1] Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5' UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.[1]

See also

References

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