Staphopain

Staphopain
Identifiers
EC number 3.4.22.48
CAS number 347841-89-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Staphopain (EC 3.4.22.48, staphylopain) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction

Broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates.

This enzyme is present in several species of Staphylococcus.

References

  1. Hofmann, B.; Hecht, H.J.; Kiess, M.; Schomburg, D. (1993). "Crystal structure of a thiol proteinase from Staphylococcus aureus V8 in the E-64 inhibitor complex". Acta Crystallographica Section A. 49: c102. doi:10.1107/s0108767378097081.
  2. Potempa, J.; Dubin, A.; Travis, J. (1998). "Staphylopain". In Barrett, A.J.; Rawlings, N.D.; Woessner, J.F. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 669–671.
  3. Dubin, G.; Chmiel, D.; Mak, P.; Rakwalska, M.; Rzychon, M.; Dubin, A. (2001). "Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis". Biol. Chem. 382: 1575–1582. doi:10.1515/bc.2001.192. PMID 11767947.
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