Sulfadiazine

Sulfadiazine
Clinical data
AHFS/Drugs.com Monograph
MedlinePlus a682130
Pregnancy
category
  • ?
Routes of
administration
Topical cream, oral
ATC code J01EC02 (WHO) QJ01EQ10 (WHO)
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
Bioavailability ?
Metabolism ?
Biological half-life ?
Excretion ?
Identifiers
CAS Number 68-35-9 YesY
PubChem (CID) 5215
DrugBank DB00359 N
ChemSpider 5026 N
UNII 0N7609K889 N
KEGG D00587 YesY
ChEMBL CHEMBL439 N
ECHA InfoCard 100.000.623
Chemical and physical data
Formula C10H10N4O2S
Molar mass 250.278 g/mol
Melting point 252 to 256 °C (486 to 493 °F)
 NYesY (what is this?)  (verify)

Sulfadiazine is a sulfonamide antibiotic.

It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.[1]

Medical uses

It eliminates bacteria that cause infections by stopping the production of folate inside the bacterial cell, and is commonly used to treat urinary tract infections, and burns.

In combination, sulfadiazine and pyrimethamine, can be used to treat toxoplasmosis, a disease caused by Toxoplasma gondii.

Mechanism of action

Sulfadiazine works by inhibiting the enzyme dihydropteroate synthetase. In combination with pyrimethamine (a dihydrofolate reductase inhibitor), sulfadiazine is used to treat active toxoplasmosis.

Side effects

Side effects reported for sulfadiazine include: nausea, upset stomach, loss of appetite, and dizziness.

Brand names

Lantrisul; Neotrizine; Sulfa-Triple #2; Sulfadiazine; Sulfaloid; Sulfonamides Duplex; Sulfose; Terfonyl; Triple Sulfa; Triple Sulfas; Triple Sulfoid

See also

References

  1. "WHO Model List of EssentialMedicines" (PDF). World Health Organization. October 2013. Retrieved 22 April 2014.
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