Survival activating factor enhancement

Survivor Activating Factor Enhancement (SAFE) is a metabolic pathway. It is an intrinsic protective signaling programme to limit cell death activated by the heart.[1] This pathway allows ischaemic postconditioning that helps protect against reperfusion injury.[2] This path involves the activation of a transcription factor called signal transducer and activator of transcription 3 (STAT3).[3]

Activation

A 2011 study concludes, “Our data demonstrate that both melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction via the SAFE pathway.”[4]

References

  1. ↑ Lecour, Sandrine (2009). "Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?". Journal of Molecular and Cellular Cardiology. 47 (1): 32–40. doi:10.1016/j.yjmcc.2009.03.019. PMID 19344728.
  2. ↑ Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway. Lydia Lacerda, Sarin Somers, Lionel H. Opie and Sandrine Lecour, Cardiovasc. Res., 2009, 84 (2), pages 201-208, doi:10.1093/cvr/cvp274
  3. ↑ When are pro-inflammatory cytokines SAFE in heart failure? Lecour Sandrine and James Richard, European heart journal, 2011, vol. 32, no6, pages 680-685, INIST:23924029
  4. ↑ Lamont KT, Somers S, Lacerda L, Opie LH, Lecour S (May 2011). "Is red wine a SAFE sip away from cardioprotection? Mechanisms involved in resveratrol- and melatonin-induced cardioprotection". J. Pineal Res. 50 (4): 374–80. doi:10.1111/j.1600-079X.2010.00853.x. PMID 21342247.


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