TAF1A

TAF1A
Identifiers
Aliases TAF1A, MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A
External IDs MGI: 109578 HomoloGene: 4155 GeneCards: TAF1A
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez

9015

21339

Ensembl

ENSG00000143498

ENSMUSG00000072258

UniProt

Q15573
Q5JRA7

P97357

RefSeq (mRNA)

NM_001201536
NM_005681
NM_139352

NM_001277957
NM_001277958
NM_001277959
NM_021466

RefSeq (protein)

NP_001188465.1
NP_005672.1
NP_647603.1

NP_001264886.1
NP_001264887.1
NP_001264888.1
NP_067441.1

Location (UCSC) Chr 1: 222.56 – 222.59 Mb Chr 1: 183.39 – 183.41 Mb
PubMed search [1] [2]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.[3][4]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[4]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A[5] and Protein SET.[5]

References

  1. "Human PubMed Reference:".
  2. "Mouse PubMed Reference:".
  3. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123. Check date values in: |year= / |date= mismatch (help)
  4. 1 2 "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
  5. 1 2 Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.

Further reading


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