TAF1C

TAF1C
Identifiers
Aliases TAF1C, MGC:39976, SL1, TAFI110, TAFI95, TATA-box binding protein associated factor, RNA polymerase I subunit C
External IDs MGI: 109576 HomoloGene: 21163 GeneCards: TAF1C
Genetically Related Diseases
autistic disorder[1]
RNA expression pattern


More reference expression data
Orthologs
Species Human Mouse
Entrez

9013

21341

Ensembl

ENSG00000103168

ENSMUSG00000031832

UniProt

Q15572

Q6PDZ2

RefSeq (mRNA)

NM_021441

RefSeq (protein)

NP_067416.2

Location (UCSC) Chr 16: 84.18 – 84.19 Mb Chr 8: 119.6 – 119.61 Mb
PubMed search [2] [3]
Wikidata
View/Edit HumanView/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit C is an enzyme that in humans is encoded by the TAF1C gene.[4][5]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the largest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.[5]

Interactions

TAF1C has been shown to interact with UBTF.[6][7]

References

  1. "Diseases that are genetically associated with TAF1C view/edit references on wikidata".
  2. "Human PubMed Reference:".
  3. "Mouse PubMed Reference:".
  4. Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (January 1995). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123. Check date values in: |year= / |date= mismatch (help)
  5. 1 2 "Entrez Gene: TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa".
  6. Voit R, Grummt I (November 2001). "Phosphorylation of UBF at serine 388 is required for interaction with RNA polymerase I and activation of rDNA transcription". Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13631–6. doi:10.1073/pnas.231071698. PMC 61092Freely accessible. PMID 11698641.
  7. Zhai W, Comai L (August 2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070Freely accessible. PMID 10913176.

Further reading


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